Changes in the level of sialic acid in plasma, brain and liver of inherently scorbutic rats during vitamin C and E deficiencies

Biosci Biotechnol Biochem. 1998 Aug;62(8):1592-3. doi: 10.1271/bbb.62.1592.


The plasma level of sialic acid (NeuAc) in inherently scorbutic [Osteogenic Disorder Shionogi (ODS)] rats was increased by 21 days of vitamin C deficiency. The brain content of NeuAc was decreased by deficiencies of these vitamins. The NeuAc level in the liver was not affected significantly by these deficiencies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed
  • Animals
  • Ascorbic Acid Deficiency / metabolism*
  • Brain / metabolism*
  • Chromatography
  • Liver / metabolism*
  • Male
  • N-Acetylneuraminic Acid / blood
  • N-Acetylneuraminic Acid / metabolism*
  • Oxidative Stress
  • Rats
  • Scurvy / metabolism
  • Vitamin E Deficiency / metabolism*


  • N-Acetylneuraminic Acid