Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death

Oncogene. 1998 Sep 17;17(11 Reviews):1475-82. doi: 10.1038/sj.onc.1202183.

Abstract

The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Caspases / metabolism
  • Cytokines / metabolism
  • Growth Substances / metabolism
  • Humans
  • MAP Kinase Kinase 3
  • Mitogen-Activated Protein Kinase Kinases*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Signal Transduction*

Substances

  • Cytokines
  • Growth Substances
  • Proto-Oncogene Proteins c-bcl-2
  • Phosphatidylinositol 3-Kinases
  • Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • MAP Kinase Kinase 3
  • MAP2K3 protein, human
  • Mitogen-Activated Protein Kinase Kinases
  • Caspases