Genetic linkage analysis of complex genetic traits by using affected sibling pairs

Biometrics. 1998 Dec;54(4):1238-46.


We provide an introduction to genetic linkage analysis. We discuss methods for the genetic analysis of common, complex disease such as diabetes, heart disease or hypertension. We describe the analysis of affected sibling pairs and discuss some of the challenges in applying these methods.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biometry / methods*
  • Diabetes Mellitus / genetics
  • Female
  • Genetic Linkage*
  • Heart Diseases / genetics
  • Humans
  • Hypertension / genetics
  • Male
  • Nuclear Family
  • Pedigree