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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1986 2
1987 2
1988 2
1989 1
1990 3
1991 4
1992 2
1993 11
1994 21
1995 33
1996 49
1997 43
1998 58
1999 74
2000 60
2001 88
2002 86
2003 99
2004 138
2005 138
2006 135
2007 131
2008 99
2009 138
2010 123
2011 110
2012 123
2013 124
2014 109
2015 137
2016 121
2017 125
2018 117
2019 150
2020 152
2021 143
2022 153
2023 127
2024 140
2025 60

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3,094 results

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Page 1
Takayasu arteritis: an update.
Keser G, Aksu K, Direskeneli H. Keser G, et al. Turk J Med Sci. 2018 Aug 16;48(4):681-697. doi: 10.3906/sag-1804-136. Turk J Med Sci. 2018. PMID: 30114347 Free article. Review.
In cases of refractory disease activity, leflunomide and biologic agents such as TNF inhibitors and tocilizumab may be tried. In selected cases with persistent lesions that cannot be reversed with medical treatment, endovascular interventions including balloon angioplasty, …
In cases of refractory disease activity, leflunomide and biologic agents such as TNF inhibitors and tocilizumab may be tried. In sele …
Leflunomide-Associated Pancytopenia.
Aldhafeeri A, Zerihun K, Khader Y, Altorok N. Aldhafeeri A, et al. Am J Ther. 2023 Nov-Dec 01;30(6):e563-e565. doi: 10.1097/MJT.0000000000001497. Epub 2022 Apr 11. Am J Ther. 2023. PMID: 35404332 No abstract available.
Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis.
Alfaro-Lara R, Espinosa-Ortega HF, Arce-Salinas CA; PRECIS study group, all physicians belong to Division of Internal Medicine. Hospital Central Sur de Pemex. Alfaro-Lara R, et al. Reumatol Clin (Engl Ed). 2019 May-Jun;15(3):133-139. doi: 10.1016/j.reuma.2017.07.020. Epub 2017 Sep 1. Reumatol Clin (Engl Ed). 2019. PMID: 28867467 Free article. English, Spanish.
OBJECTIVE: To assess the efficacy and side effects of methotrexate and leflunomide in patients with rheumatoid arthritis (RA) as the first disease-modifying antirheumatic drug (DMARD). ...Leflunomide was linked to a greater increase in liver enzymes, but there were …
OBJECTIVE: To assess the efficacy and side effects of methotrexate and leflunomide in patients with rheumatoid arthritis (RA) as the …
Therapeutic management in paediatric alopecia areata: A systematic review.
Waśkiel-Burnat A, Kołodziejak M, Sikora M, Stochmal A, Rakowska A, Olszewska M, Rudnicka L. Waśkiel-Burnat A, et al. J Eur Acad Dermatol Venereol. 2021 Jun;35(6):1299-1308. doi: 10.1111/jdv.17187. J Eur Acad Dermatol Venereol. 2021. PMID: 33630354 Review.
There were limited data considering children with alopecia areata treated with azathioprine, hydroxychloroquine, topical sildenafil, topical prostaglandin analogues, fractional carbon dioxide laser, leflunomide, mesalazine, apremilast, dupilumab, ustekinumab, efalizumab, b …
There were limited data considering children with alopecia areata treated with azathioprine, hydroxychloroquine, topical sildenafil, topical …
Leflunomide: dermatologic perspective.
Sehgal VN, Verma P. Sehgal VN, et al. J Dermatolog Treat. 2013 Apr;24(2):89-95. doi: 10.3109/09546634.2011.595383. Epub 2011 Jul 31. J Dermatolog Treat. 2013. PMID: 21801113 Free article. Review.
Leflunomide, an isoxazole derivative, is a disease-modifying antirheumatic drug. It has successfully been used for the treatment of rheumatoid arthritis as a feasible alternative to methotrexate. ...Prime mode of action of leflunomide is through the inhibition of di …
Leflunomide, an isoxazole derivative, is a disease-modifying antirheumatic drug. It has successfully been used for the treatment of r …
Mitochondrial elongation impairs breast cancer metastasis.
Minarrieta L, Annis MG, Audet-Delage Y, Kuasne H, Pacis A, St-Louis C, Nowakowski A, Biondini M, Khacho M, Park M, Siegel PM, St-Pierre J. Minarrieta L, et al. Sci Adv. 2024 Nov 8;10(45):eadm8212. doi: 10.1126/sciadv.adm8212. Epub 2024 Nov 6. Sci Adv. 2024. PMID: 39504368 Free PMC article.
To study the impact of mitochondrial dynamics on metastasis, we promoted mitochondrial elongation in metastatic breast cancer cells by individual genetic deletion of three key regulators of mitochondrial fission (Drp1, Fis1, Mff) or by pharmacological intervention with lefluno …
To study the impact of mitochondrial dynamics on metastasis, we promoted mitochondrial elongation in metastatic breast cancer cells by indiv …
Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway.
Jiang X, Wang W, Lei L, Feng T, Hu Y, Liu P, Li Y, Sheng R, Zhang Y, Li S, Zhang J, Zhang Y, Jin ZG, Tian Z, Jiang J, Xu Y, Si S. Jiang X, et al. Int J Biol Sci. 2024 Jul 2;20(10):3725-3741. doi: 10.7150/ijbs.93465. eCollection 2024. Int J Biol Sci. 2024. PMID: 39113703 Free PMC article.
The probability of cardiovascular events has been reported lower in rheumatoid arthritis (RA) patients treated with leflunomide. However, the anti-atherosclerotic and cardiovascular protective effects and metabolism of leflunomide are not explored. In this study, we …
The probability of cardiovascular events has been reported lower in rheumatoid arthritis (RA) patients treated with leflunomide. Howe …
Leflunomide in dermatology.
Boyd AS. Boyd AS. J Am Acad Dermatol. 2012 Apr;66(4):673-9. doi: 10.1016/j.jaad.2011.08.025. Epub 2011 Oct 1. J Am Acad Dermatol. 2012. PMID: 21962758 Review.
Leflunomide is an oral disease-modifying antirheumatic drug administered to patients with rheumatoid and psoriatic arthritis. This drug inhibits dihydroorotate dehydrogenase, an enzyme critical in the production of intracellular pyrimidines, and down-regulates tumor necros …
Leflunomide is an oral disease-modifying antirheumatic drug administered to patients with rheumatoid and psoriatic arthritis. This dr …
Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against alphaPD1-induced cardiotoxicity in mice.
Huang R, Shen ZY, Huang D, Zhao SH, Dan LX, Wu P, Tang QZ, Ma ZG. Huang R, et al. Nat Commun. 2025 Mar 19;16(1):2651. doi: 10.1038/s41467-025-58107-8. Nat Commun. 2025. PMID: 40108157 Free PMC article.
Anti-programmed death 1 (alphaPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular toxicity. Leflunomide (Lef) can suppress the growth of several tumor and mitigate cardiac remodeling in mice. ...
Anti-programmed death 1 (alphaPD1) immune checkpoint blockade is used in combination for cancer treatment but associated with cardiovascular …
Cost-Effectiveness of Biosimilars vs Leflunomide in Patients With Rheumatoid Arthritis.
Peng K, Chan SCW, Wang Y, Cheng FWT, Yeung WWY, Jiao Y, Chan EWY, Wong ICK, Lau CS, Li X. Peng K, et al. JAMA Netw Open. 2024 Jun 3;7(6):e2418800. doi: 10.1001/jamanetworkopen.2024.18800. JAMA Netw Open. 2024. PMID: 38922614 Free PMC article.
Both biosimilar sequences presented lower costs and greater QALYs than the leflunomide sequence. In the deterministic sensitivity analysis, the incremental cost-effectiveness ratio (US$/QALY) comparing biosimilar infliximab sequence vs leflunomide sequence and biosi …
Both biosimilar sequences presented lower costs and greater QALYs than the leflunomide sequence. In the deterministic sensitivity ana …
3,094 results