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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 1
1989 3
1990 1
1993 2
1994 4
1995 2
1996 4
1997 1
1998 7
1999 1
2000 3
2001 10
2002 10
2003 11
2004 12
2005 11
2006 6
2007 12
2008 18
2009 11
2010 19
2011 18
2012 14
2013 17
2014 12
2015 7
2016 9
2017 2
2018 7
2019 6
2020 4
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2023 2
2024 1

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235 results

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Page 1
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
AIM-HIGH Investigators; Boden WE, Probstfield JL, Anderson T, Chaitman BR, Desvignes-Nickens P, Koprowicz K, McBride R, Teo K, Weintraub W. AIM-HIGH Investigators, et al. N Engl J Med. 2011 Dec 15;365(24):2255-67. doi: 10.1056/NEJMoa1107579. Epub 2011 Nov 15. N Engl J Med. 2011. PMID: 22085343 Free article. Clinical Trial.
BACKGROUND: In patients with established cardiovascular disease, residual cardiovascular risk persists despite the achievement of target low-density lipoprotein (LDL) cholesterol levels with statin therapy. It is unclear whether extended-release niacin added to simvasta …
BACKGROUND: In patients with established cardiovascular disease, residual cardiovascular risk persists despite the achievement of target low …
Niacin extended-release/simvastatin.
Sanford M, Curran MP. Sanford M, et al. Drugs. 2008;68(16):2373-86. doi: 10.2165/0003495-200868160-00008. Drugs. 2008. PMID: 18973399 Review.
Niacin extended-release (ER)/simvastatin is a once-daily, fixed-dose combination of the HMG-CoA reductase inhibitor simvastatin and an ER formulation of niacin (a B-complex vitamin). In healthy volunteers who were given niacin ER/simvastatin …
Niacin extended-release (ER)/simvastatin is a once-daily, fixed-dose combination of the HMG-CoA reductase inhibitor simvast …
Safety of niacin and simvastatin combination therapy.
Bays H. Bays H. Am J Cardiol. 2008 Apr 17;101(8A):3B-8B. doi: 10.1016/j.amjcard.2008.02.026. Am J Cardiol. 2008. PMID: 18375239 Review.
Niacin's major adverse experience (AE) is flushing. Niacin may also increase glucose levels, liver enzymes, and uric acid levels and cause other AEs that may have clinical relevance in selected patients. ...Equally important is ensuring that the combination o …
Niacin's major adverse experience (AE) is flushing. Niacin may also increase glucose levels, liver enzymes, and uric ac …
Lipid-lowering drugs.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2022 Sep 19;64(1659):145-152. Med Lett Drugs Ther. 2022. PMID: 36094548 No abstract available.
Lipid-lowering drugs.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2019 Feb 11;61(1565):17-24. Med Lett Drugs Ther. 2019. PMID: 30845106 No abstract available.
Effects of extended-release niacin/laropiprant, simvastatin, and the combination on correlations between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients with dyslipidemia.
Farnier M, Chen E, Johnson-Levonas AO, McCrary Sisk C, Mitchel YB. Farnier M, et al. Vasc Health Risk Manag. 2014 May 7;10:279-90. doi: 10.2147/VHRM.S58694. eCollection 2014. Vasc Health Risk Manag. 2014. PMID: 24855368 Free PMC article. Clinical Trial.
BACKGROUND: Statins modify correlations between apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C) and apoB and non-high-density lipoprotein cholesterol (non-HDL-C); however, it is not known whether niacin-based therapies have similar effects. OBJECTIV …
BACKGROUND: Statins modify correlations between apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C) and apoB and non-hig …
Effects of Extended-Release Niacin and Extended-Release Niacin/Laropiprant on the Pharmacokinetics of Simvastatin in Healthy Subjects.
Lauring B, Dishy V, De Kam PJ, Crumley T, Wenning L, Liu F, Sisk C, Wagner J, Lai E. Lauring B, et al. Am J Ther. 2015 Sep-Oct;22(5):367-76. doi: 10.1097/MJT.0000000000000051. Am J Ther. 2015. PMID: 24832384 Clinical Trial.
Study 1 used single doses of extended-release niacin and simvastatin; study 2 used multiple-dose coadministration of extended-release niacin/laropiprant and simvastatin in healthy subjects; and study 3 used single doses of both extended-release niac …
Study 1 used single doses of extended-release niacin and simvastatin; study 2 used multiple-dose coadministration of extended- …
In Vitro Targeted Delivery of Simvastatin and Niacin to Macrophages Using Mannan-Grafted Magnetite Nanoparticles.
Rastegari B, Ghamar Talepoor A, Khosropanah S, Doroudchi M. Rastegari B, et al. ACS Omega. 2023 Dec 18;9(1):658-674. doi: 10.1021/acsomega.3c06389. eCollection 2024 Jan 9. ACS Omega. 2023. PMID: 38222576 Free PMC article.
The low dosage of simvastatin decreased both IL-6 and ARG1 expressions, while niacin and combined simvastatin/niacin increased the level of ARG1 expression significantly. Toxicity evaluations on human umbilical vein endothelial cells and murine liver c …
The low dosage of simvastatin decreased both IL-6 and ARG1 expressions, while niacin and combined simvastatin/niacin …
Simvastatin: present and future perspectives.
Robinson JG. Robinson JG. Expert Opin Pharmacother. 2007 Sep;8(13):2159-27. doi: 10.1517/14656566.8.13.2159. Expert Opin Pharmacother. 2007. PMID: 17714068 Review.
At doses of 5 - 80 mg, simvastatin lowers LDL cholesterol by 25 - 50%. Simvastatin has been shown to reduce the risk of cardiovascular disease by 35% and overall mortality by up to 30% over 5 years. ...Coformulation of simvastatin with ezetimibe is now availa …
At doses of 5 - 80 mg, simvastatin lowers LDL cholesterol by 25 - 50%. Simvastatin has been shown to reduce the risk of cardio …
Management of complex lipid abnormalities with a fixed dose combination of simvastatin and extended release niacin.
Robinson JG. Robinson JG. Vasc Health Risk Manag. 2009;5(1):31-43. doi: 10.2147/vhrm.s3190. Epub 2009 Apr 8. Vasc Health Risk Manag. 2009. PMID: 19436666 Free PMC article. Review.
ER niacin 1000 mg combined with simvastatin 20 mg reduced LDL-C by 6%, non-HDL-C by 7%, and triglycerides by 13%, and raised HDL-C by 11% compared to simvastatin 20 mg alone. ...However, drop-out rates were high in both the simvastatin and ER niacin …
ER niacin 1000 mg combined with simvastatin 20 mg reduced LDL-C by 6%, non-HDL-C by 7%, and triglycerides by 13%, and raised H …
235 results