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Taking a holistic view of PEST-containing nuclear protein (PCNP) in cancer biology.
Afzal A, Sarfraz M, Li GL, Ji SP, Duan SF, Khan NH, Wu DD, Ji XY. Afzal A, et al. Cancer Med. 2019 Oct;8(14):6335-6343. doi: 10.1002/cam4.2465. Epub 2019 Sep 5. Cancer Med. 2019. PMID: 31487123 Free PMC article. Review.
A PEST containing nuclear protein (PCNP) was demonstrated as a tumor suppressor in a neuroblastoma cancer model and tumor promoter in lung adenocarcinoma cancer model. ...Hence, we demonstrate PCNP as a novel target in cancer diagnosis and treatment....
A PEST containing nuclear protein (PCNP) was demonstrated as a tumor suppressor in a neuroblastoma cancer model and tumor prom …
Biology of PEST-Containing Nuclear Protein: A Potential Molecular Target for Cancer Research.
Khan NH, Chen HJ, Fan Y, Surfaraz M, Ahammad MF, Qin YZ, Shahid M, Virk R, Jiang E, Wu DD, Ji XY. Khan NH, et al. Front Oncol. 2022 Feb 4;12:784597. doi: 10.3389/fonc.2022.784597. eCollection 2022. Front Oncol. 2022. PMID: 35186732 Free PMC article. Review.
PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in vital cellular processes like cell proliferation and mediates tumorigenesis. PCNP is a short-living, small nuclear protein of only 178 amino acids with two remarkable PEST …
PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in vital cellular processes like cell proliferati …
PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma.
Wang DY, Hong Y, Chen YG, Dong PZ, Liu SY, Gao YR, Lu D, Li HM, Li T, Guo JC, He F, Ren XQ, Sun SY, Wu DD, Duan SF, Ji XY. Wang DY, et al. Oncogenesis. 2019 Mar 14;8(3):22. doi: 10.1038/s41389-019-0132-4. Oncogenesis. 2019. PMID: 30872582 Free PMC article.
Lung cancer is the leading cause of cancer-related mortality worldwide. PEST-containing nuclear protein (PCNP) has been found in the nucleus of cancer cells. ...Furthermore, PCNP can be a novel therapeutic target and potent PCNP inhibitors can be desig …
Lung cancer is the leading cause of cancer-related mortality worldwide. PEST-containing nuclear protein (PCNP) has been found …
Recent Insights into the Roles of PEST-Containing Nuclear Protein.
Guo S, Ding R, Zhao Q, Wang X, Lv S, Ji XY. Guo S, et al. Mol Biotechnol. 2024 May 19. doi: 10.1007/s12033-024-01188-5. Online ahead of print. Mol Biotechnol. 2024. PMID: 38762838 Review.
PEST-containing nuclear protein (PCNP), a short-lived small nuclear protein with 178 amino acids, is a nuclear protein containing two PEST sequences. ...The main relevant articles were retrieved from PubMed, with keywords such as PEST-containing nuclea …
PEST-containing nuclear protein (PCNP), a short-lived small nuclear protein with 178 amino acids, is a nuclear protein contain …
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Wu DD, Gao YR, Li T, Wang DY, Lu D, Liu SY, Hong Y, Ning HB, Liu JP, Shang J, Shi JF, Wei JS, Ji XY. Wu DD, et al. BMC Cancer. 2018 May 2;18(1):499. doi: 10.1186/s12885-018-4391-9. BMC Cancer. 2018. PMID: 29716528 Free PMC article.
BACKGROUND: PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in cell proliferation and tumorigenesis. ...RESULTS: PCNP over-expression decreased the proliferation, migration, and invasion of human neuroblastoma cells and down-regul …
BACKGROUND: PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in cell proliferation and tumorigenes …
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Chen YG, Liu HX, Hong Y, Dong PZ, Liu SY, Gao YR, Lu D, Li T, Wang DY, Wu DD, Ji XY. Chen YG, et al. Int J Biol Sci. 2022 May 16;18(9):3605-3620. doi: 10.7150/ijbs.70394. eCollection 2022. Int J Biol Sci. 2022. PMID: 35813472 Free PMC article.
Thyroid cancer (TC) has increased globally, with a prominent increase in small, papillary thyroid cancers. PEST-containing nuclear protein (PCNP), a nuclear protein, has been found to be associated with human cancers in recent years. ...Furthermore, PCNP over …
Thyroid cancer (TC) has increased globally, with a prominent increase in small, papillary thyroid cancers. PEST-containing nuclear pr …
PCNP promotes ovarian cancer progression by accelerating beta-catenin nuclear accumulation and triggering EMT transition.
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X. Dong P, et al. J Cell Mol Med. 2020 Jul;24(14):8221-8235. doi: 10.1111/jcmm.15491. Epub 2020 Jun 16. J Cell Mol Med. 2020. PMID: 32548978 Free PMC article.
Ever reports showed that PCNP is associated with human cancers including neuroblastoma and lung cancer. However, the role and underlying molecular mechanism of PCNP in ovarian cancer have not been plenty elucidated. Herein, we first investigated the expression of …
Ever reports showed that PCNP is associated with human cancers including neuroblastoma and lung cancer. However, the role and underly …
NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.
Mori T, Li Y, Hata H, Kochi H. Mori T, et al. FEBS Lett. 2004 Jan 16;557(1-3):209-14. doi: 10.1016/s0014-5793(03)01495-9. FEBS Lett. 2004. PMID: 14741369 Free article.
We previously reported the association of a novel Np95/ICBP90-like RING finger protein (NIRF) with a novel PEST-containing nuclear protein (PCNP). NIRF is a nuclear protein with a ubiquitin-like domain, a PHD finger, a YDG/SRA domain, Rb-binding motifs and a RING fi …
We previously reported the association of a novel Np95/ICBP90-like RING finger protein (NIRF) with a novel PEST-containing nuclear pr …
Tissue mechanics modulate PCNP expression in oral squamous cell carcinomas with different differentiation.
Zhang L, Guo D, Shen J, Zheng Y, Zhai J, Li R, He D, Zhang B. Zhang L, et al. Front Oncol. 2023 Jan 10;12:1072276. doi: 10.3389/fonc.2022.1072276. eCollection 2022. Front Oncol. 2023. PMID: 36703786 Free PMC article.
BACKGROUND: PEST-containing nuclear protein (PCNP), a novel zinc finger protein, participates in cell cycle regulation. ...Patients with high PCNP expression had a higher survival rate than those with low PCNP expression. ...
BACKGROUND: PEST-containing nuclear protein (PCNP), a novel zinc finger protein, participates in cell cycle regulation. ...Pat …
TIPE2 and PCNP expression abnormalities in peripheral blood mononuclear cells associated with disease activity in rheumatoid arthritis: a meta-analysis.
Han ZP, Yang Y, Chen HY, Zhong MY, Zhuang GH. Han ZP, et al. Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1242-1249. doi: 10.26355/eurrev_202102_24828. Eur Rev Med Pharmacol Sci. 2021. PMID: 33629294 Free article. Review.
Tumor necrosis induced protein 8-like 2 (TIPE2), closely related to PEST-containing nuclear protein (PCNP) expression, is an immune-related protein potentially involved in the pathogenesis of autoimmune diseases. In this study, we aimed to assess differential expres …
Tumor necrosis induced protein 8-like 2 (TIPE2), closely related to PEST-containing nuclear protein (PCNP) expression, is an i …
13 results