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2004 3
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2015 3
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Page 1
GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Kroef V, Ruegenberg S, Horn M, Allmeroth K, Ebert L, Bozkus S, Miethe S, Elling U, Schermer B, Baumann U, Denzel MS. Kroef V, et al. Elife. 2022 Mar 1;11:e69223. doi: 10.7554/eLife.69223. Elife. 2022. PMID: 35229715 Free PMC article.
This HBP configuration in which AMDHD2 serves to balance GFPT2 activity was also observed in other mESCs and, consistently, the GFPT2:GFPT1 ratio decreased with differentiation of human embryonic stem cells. Taken together, our data reveal a critical function of AMD …
This HBP configuration in which AMDHD2 serves to balance GFPT2 activity was also observed in other mESCs and, consistently, the GF …
GFPT2 promotes metastasis and forms a positive feedback loop with p65 in colorectal cancer.
Liu L, Pan Y, Ren X, Zeng Z, Sun J, Zhou K, Liang Y, Wang F, Yan Y, Liao W, Ding Y, Liu X, Liang L. Liu L, et al. Am J Cancer Res. 2020 Aug 1;10(8):2510-2522. eCollection 2020. Am J Cancer Res. 2020. PMID: 32905539 Free PMC article.
Here, we found that GFPT2 promoted the proliferation, migration, invasion and metastasis of colorectal cancer (CRC) cells. Mechanically, p65 acted as an upstream transcription factor of GFPT2 and regulated its expression and function. In turn, GFPT2 enhanced …
Here, we found that GFPT2 promoted the proliferation, migration, invasion and metastasis of colorectal cancer (CRC) cells. Mechanical …
Roles of GFPT2 Expression Levels on the Prognosis and Tumor Microenvironment of Colon Cancer.
Ding X, Liu H, Yuan Y, Zhong Q, Zhong X. Ding X, et al. Front Oncol. 2022 Mar 7;12:811559. doi: 10.3389/fonc.2022.811559. eCollection 2022. Front Oncol. 2022. PMID: 35330716 Free PMC article.
The levels of GFPT2 and drug sensitivity data were performed from CellMiner dataset. ...In addition, GFPT2 expression was correlated with the tumor microenvironment (TME). ...
The levels of GFPT2 and drug sensitivity data were performed from CellMiner dataset. ...In addition, GFPT2 expression was corr …
Cancer-associated fibroblast expression of glutamine fructose-6-phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer.
Yang S, Li G, Yin X, Wang Y, Jiang X, Bian X, Fang T, Yin S, Zhang L, Xue Y. Yang S, et al. J Pathol Clin Res. 2023 Sep;9(5):391-408. doi: 10.1002/cjp2.333. Epub 2023 Jul 3. J Pathol Clin Res. 2023. PMID: 37395335 Free PMC article.

The mRNA of GFPT2 was highly expressed in the tumor (p < 0.001), and GC cells and tumors expressed high levels of GFPT2 protein. ...The ESTIMATE, CIBERSORT, and ssGSEA algorithms showed that GFPT2 was associated with immune cell infiltration. In addition,

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The mRNA of GFPT2 was highly expressed in the tumor (p < 0.001), and GC cells and tumors expressed high levels of GFPT2 pro

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The GFPT2-O-GlcNAcylation-YBX1 axis promotes IL-18 secretion to regulate the tumor immune microenvironment in pancreatic cancer.
Zhang HR, Li TJ, Yu XJ, Liu C, Wu WD, Ye LY, Jin KZ. Zhang HR, et al. Cell Death Dis. 2024 Apr 4;15(4):244. doi: 10.1038/s41419-024-06589-7. Cell Death Dis. 2024. PMID: 38575607 Free PMC article.
The immunosuppressive microenvironment caused by several intrinsic and extrinsic mechanism has brought great challenges to the immunotherapy of pancreatic cancer. We identified GFPT2, the key enzyme in hexosamine biosynthesis pathway (HBP), as an immune-related prognostic …
The immunosuppressive microenvironment caused by several intrinsic and extrinsic mechanism has brought great challenges to the immunotherapy …
GFPT2-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma.
Zhang W, Bouchard G, Yu A, Shafiq M, Jamali M, Shrager JB, Ayers K, Bakr S, Gentles AJ, Diehn M, Quon A, West RB, Nair V, van de Rijn M, Napel S, Plevritis SK. Zhang W, et al. Cancer Res. 2018 Jul 1;78(13):3445-3457. doi: 10.1158/0008-5472.CAN-17-2928. Epub 2018 May 14. Cancer Res. 2018. PMID: 29760045 Free PMC article.
GFPT2 was predictive of glucose uptake independent of GLUT1, the primary glucose transporter, and was prognostically significant at both gene and protein level. We confirmed that normal fibroblasts transformed to CAF-like cells, following TGFbeta treatment, upregulated HBP …
GFPT2 was predictive of glucose uptake independent of GLUT1, the primary glucose transporter, and was prognostically significant at b …
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ. Kim J, et al. Nat Metab. 2020 Dec;2(12):1401-1412. doi: 10.1038/s42255-020-00316-0. Epub 2020 Nov 30. Nat Metab. 2020. PMID: 33257855 Free PMC article.
KRAS/LKB1 co-mutant cells contain high levels of HBP metabolites, higher flux through the HBP pathway and elevated dependence on the HBP enzyme glutamine-fructose-6-phosphate transaminase [isomerizing] 2 (GFPT2). GFPT2 inhibition selectively reduced KRAS/LKB1 co-mut …
KRAS/LKB1 co-mutant cells contain high levels of HBP metabolites, higher flux through the HBP pathway and elevated dependence on the HBP enz …
Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition.
Li J, Ye Y, Liu Z, Zhang G, Dai H, Li J, Zhou B, Li Y, Zhao Q, Huang J, Feng J, Liu S, Ruan P, Wang J, Liu J, Huang M, Liu X, Yu S, Liang Z, Ma L, Gou X, Zhang G, Chen N, Lu Y, Di C, Xia Q, Pan J, Feng R, Cai Q, Su S. Li J, et al. Nat Cancer. 2022 Apr;3(4):453-470. doi: 10.1038/s43018-022-00354-5. Epub 2022 Apr 28. Nat Cancer. 2022. PMID: 35484420
GFPT2-mediated excessive use of glutamine by tumor cells impairs mitochondrial fission and prevents access of PKC-teta to compartmentalized WIP in macrophages. Our data suggest that mitochondrial dynamics dictate the phase transition of the phagocytic machinery and identif …
GFPT2-mediated excessive use of glutamine by tumor cells impairs mitochondrial fission and prevents access of PKC-teta to compartment …
Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative Stress.
Wang Q, Karvelsson ST, Kotronoulas A, Gudjonsson T, Halldorsson S, Rolfsson O. Wang Q, et al. Mol Cell Proteomics. 2022 Feb;21(2):100185. doi: 10.1016/j.mcpro.2021.100185. Epub 2021 Dec 17. Mol Cell Proteomics. 2022. PMID: 34923141 Free PMC article.
Comparative analysis of D492 and D492M to tumorigenic D492HER2 differentiated metabolic markers of migration from those of invasion. Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) was one of the top dysregulated enzymes in D492HER2. Gene expression analysis of the c …
Comparative analysis of D492 and D492M to tumorigenic D492HER2 differentiated metabolic markers of migration from those of invasion. Glutami …
Identification of a homozygous GFPT2 variant in a family with asthenozoospermia.
Askari M, Kordi-Tamandani DM, Almadani N, McElreavey K, Totonchi M. Askari M, et al. Gene. 2019 May 30;699:16-23. doi: 10.1016/j.gene.2019.02.060. Epub 2019 Mar 5. Gene. 2019. PMID: 30849544
Candidate pathogenic variants were screened in a control cohort of 400 ancestry-matched Iranian fertile men, 30 unrelated men with idiopathic ASZ, and public databases. RESULTS: A rare mutation in GFPT2 gene (c.1097G > A; p.Arg366Gln) located in the SIS 1 domain was seg …
Candidate pathogenic variants were screened in a control cohort of 400 ancestry-matched Iranian fertile men, 30 unrelated men with idiopathi …
75 results