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2000 1
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2008 6
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Page 1
Bis-Thiourea Chiral Sensor for the NMR Enantiodiscrimination of N-Acetyl and N-Trifluoroacetyl Amino Acid Derivatives.
Recchimurzo A, Balzano F, Uccello Barretta G, Gherardi L. Recchimurzo A, et al. J Org Chem. 2022 Sep 16;87(18):11968-11978. doi: 10.1021/acs.joc.2c00814. Epub 2022 Sep 5. J Org Chem. 2022. PMID: 36062357 Free PMC article.
A C2-symmetrical bis-thiourea chiral solvating agent (CSA), TFTDA, for NMR spectroscopy has been obtained by reacting (1R,2R)-1,2-bis(2-hydroxyphenyl)ethylenediamine and 3,5-bis(trifluoromethyl)phenyl isothiocyanate. ...
A C2-symmetrical bis-thiourea chiral solvating agent (CSA), TFTDA, for NMR spectroscopy has been obtained by reacting (1R,2R)- …
Stereospecific Furanosylations Catalyzed by Bis-thiourea Hydrogen-Bond Donors.
Mayfield AB, Metternich JB, Trotta AH, Jacobsen EN. Mayfield AB, et al. J Am Chem Soc. 2020 Feb 26;142(8):4061-4069. doi: 10.1021/jacs.0c00335. Epub 2020 Feb 14. J Am Chem Soc. 2020. PMID: 32013410 Free PMC article.
We report a new method for stereoselective O-furanosylation reactions promoted by a precisely tailored bis-thiourea hydrogen-bond-donor catalyst. Furanosyl donors outfitted with an anomeric dialkylphosphate leaving group undergo substitution with high anomeric selec …
We report a new method for stereoselective O-furanosylation reactions promoted by a precisely tailored bis-thiourea hydrogen-b …
Macrocyclic bis-thioureas catalyze stereospecific glycosylation reactions.
Park Y, Harper KC, Kuhl N, Kwan EE, Liu RY, Jacobsen EN. Park Y, et al. Science. 2017 Jan 13;355(6321):162-166. doi: 10.1126/science.aal1875. Science. 2017. PMID: 28082586 Free PMC article.
In particular, stereochemical outcomes in glycosylation reactions are highly dependent on the steric and electronic properties of coupling partners; thus, carbohydrate synthesis is not easily predictable. Here we report the discovery of a macrocyclic bis-thiourea de …
In particular, stereochemical outcomes in glycosylation reactions are highly dependent on the steric and electronic properties of coupling p …
Diamine-Tethered Bis(thiourea) Organocatalyst for Asymmetric Henry Reaction.
Otevrel J, Bobal P. Otevrel J, et al. J Org Chem. 2017 Aug 18;82(16):8342-8358. doi: 10.1021/acs.joc.7b00079. Epub 2017 Jul 31. J Org Chem. 2017. PMID: 28715189
We have developed a novel multifunctional C(2)-symmetric biphenyl-based diamine-tethered bis(thiourea) organocatalyst, which was tested in the asymmetric Henry reaction. ...
We have developed a novel multifunctional C(2)-symmetric biphenyl-based diamine-tethered bis(thiourea) organocatalyst, which w …
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.
Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM. Verlinden BK, et al. Bioorg Med Chem. 2015 Aug 15;23(16):5131-43. doi: 10.1016/j.bmc.2015.01.036. Epub 2015 Jan 28. Bioorg Med Chem. 2015. PMID: 25684422 Free PMC article.
A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. ...Preliminary biological evaluation of the polyamine analogue antiplasmodial phenotype revealed …
A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated i …
Chiral recognition of neutral guests by chiral naphthotubes with a bis-thiourea endo-functionalized cavity.
Wang SM, Wang YF, Huang L, Zheng LS, Nian H, Zheng YT, Yao H, Jiang W, Wang X, Yang LP. Wang SM, et al. Nat Commun. 2023 Sep 13;14(1):5645. doi: 10.1038/s41467-023-41390-8. Nat Commun. 2023. PMID: 37704639 Free PMC article.
This study presents two pairs of chiral naphthotubes containing a bis-thiourea endo-functionalized cavity. Each chiral naphthotube has two homochiral centers which were fixed adjacent to the thiourea groups, causing the skeleton and thiourea groups to twist enantiom …
This study presents two pairs of chiral naphthotubes containing a bis-thiourea endo-functionalized cavity. Each chiral naphtho …
Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities.
Verlinden BK, Niemand J, Snyman J, Sharma SK, Beattie RJ, Woster PM, Birkholtz LM. Verlinden BK, et al. J Med Chem. 2011 Oct 13;54(19):6624-33. doi: 10.1021/jm200463z. Epub 2011 Sep 14. J Med Chem. 2011. PMID: 21882831 Free PMC article.
A series of alkylated (bis)urea and (bis)thiourea polyamine analogues were synthesized and screened for antimalarial activity against chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. ...
A series of alkylated (bis)urea and (bis)thiourea polyamine analogues were synthesized and screened for antimalarial activity …
76 results