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558 results

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Page 1
Fumarylacetoacetate hydrolase gene as a knockout target for hepatic chimerism and donor liver production.
Larson EL, Joo DJ, Nelson ED, Amiot BP, Aravalli RN, Nyberg SL. Larson EL, et al. Stem Cell Reports. 2021 Nov 9;16(11):2577-2588. doi: 10.1016/j.stemcr.2021.09.018. Epub 2021 Oct 21. Stem Cell Reports. 2021. PMID: 34678209 Free PMC article. Review.
We review proposed mutations in the recipient embryo to disable hepatogenesis, and discuss the advantages of using fumarylacetoacetate hydrolase knockouts and other genetic modifications to disable hepatogenesis. ...
We review proposed mutations in the recipient embryo to disable hepatogenesis, and discuss the advantages of using fumarylacetoacetate …
The fumarylacetoacetate hydrolase (FAH) superfamily of enzymes: multifunctional enzymes from microbes to mitochondria.
Weiss AKH, Loeffler JR, Liedl KR, Gstach H, Jansen-Dürr P. Weiss AKH, et al. Biochem Soc Trans. 2018 Apr 17;46(2):295-309. doi: 10.1042/BST20170518. Epub 2018 Feb 27. Biochem Soc Trans. 2018. PMID: 29487229 Review.
Prokaryotic and eukaryotic fumarylacetoacetate hydrolase (FAH) superfamily members, sharing conserved regions that form the so-called FAH-domain, catalyze a remarkable variety of reactions. ...
Prokaryotic and eukaryotic fumarylacetoacetate hydrolase (FAH) superfamily members, sharing conserved regions that form the so …
Fumarylacetoacetate hydrolase is required for fertility in rice.
Hu C, Huang L, Chen Y, Liu J, Wang Z, Gao B, Zhu Q, Ren C. Hu C, et al. Planta. 2021 May 18;253(6):122. doi: 10.1007/s00425-021-03632-1. Planta. 2021. PMID: 34003383
Loss of OsFAH causes rice sterility. Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the tyrosine (Tyr) degradation pathway that is crucial for animals. ...
Loss of OsFAH causes rice sterility. Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the tyrosine (Tyr) degradation …
Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer.
Li J, Zheng C, Mai Q, Huang X, Pan W, Lu J, Chen Z, Zhang S, Zhang C, Huang H, Chen Y, Guo H, Wu Z, Deng C, Jiang Y, Li B, Liu J, Yao S, Pan C. Li J, et al. Cell Metab. 2023 Nov 7;35(11):2044-2059.e8. doi: 10.1016/j.cmet.2023.10.002. Epub 2023 Oct 26. Cell Metab. 2023. PMID: 37890478
Here, we report that the depletion of fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the final step of tyrosine catabolism, reduced chemosensitivity in epithelial ovarian cancer (EOC). ...
Here, we report that the depletion of fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the final step of tyrosine …
Mutations in the fumarylacetoacetate hydrolase gene causing hereditary tyrosinemia type I: overview.
St-Louis M, Tanguay RM. St-Louis M, et al. Hum Mutat. 1997;9(4):291-9. doi: 10.1002/(SICI)1098-1004(1997)9:4<291::AID-HUMU1>3.0.CO;2-9. Hum Mutat. 1997. PMID: 9101289 Review.
Tyrosinemia type I is an inborn error of metabolism caused by a deficiency in the last enzyme of the tyrosine catabolic pathway, fumarylacetoacetate hydrolase (FAH). The disease has been reported worldwide with varying incidence. ...
Tyrosinemia type I is an inborn error of metabolism caused by a deficiency in the last enzyme of the tyrosine catabolic pathway, fumaryla …
Fumarylacetoacetate hydrolase is involved in salt stress response in Arabidopsis.
Huang L, Hu C, Cai W, Zhu Q, Gao B, Zhang X, Ren C. Huang L, et al. Planta. 2018 Aug;248(2):499-511. doi: 10.1007/s00425-018-2907-9. Epub 2018 May 21. Planta. 2018. PMID: 29785518
Fumarylacetoacetate hydrolase participates in positive regulation of salt stress in Arabidopsis. Fumarylacetoacetate hydrolase (FAH) catalyzes the hydrolysis of fumarylacetoacetate into fumarate and acetoacetate, the final step in the Tyr degradation p …
Fumarylacetoacetate hydrolase participates in positive regulation of salt stress in Arabidopsis. Fumarylacetoacetate …
Nitisinone.
Elder AJ, Ali S. Elder AJ, et al. 2023 Jul 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 36943996 Free Books & Documents.
HT-1 is an autosomal recessive disease caused by a deficiency in fumarylacetoacetate hydrolase (FAH), the last enzyme in the tyrosine degradation pathway. This activity reviews the indications, action, and contraindications for nitisinone as a valuable agent in trea …
HT-1 is an autosomal recessive disease caused by a deficiency in fumarylacetoacetate hydrolase (FAH), the last enzyme in the t …
Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1.
Li L, Zhang Q, Yang H, Zou Q, Lai C, Jiang F, Zhao P, Luo Z, Yang J, Chen Q, Wang Y, Newsome PN, Frampton J, Maxwell PH, Li W, Chen S, Wang D, Siu TS, Tam S, Tse HF, Qin B, Bao X, Esteban MA, Lai L. Li L, et al. J Biol Chem. 2017 Mar 17;292(11):4755-4763. doi: 10.1074/jbc.M116.764787. Epub 2017 Jan 4. J Biol Chem. 2017. PMID: 28053091 Free PMC article.
Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation.
Bai Y, Yang Z, Xu X, Ding W, Qi J, Liu F, Wang X, Zhou B, Zhang W, Zhuang X, Li G, Zhao Y. Bai Y, et al. Hepatology. 2023 May 1;77(5):1550-1565. doi: 10.1002/hep.32686. Epub 2023 Apr 17. Hepatology. 2023. PMID: 35881538
RNA sequencing analysis, metabolic assays, and in vivo physiological experiments show that chemically induced hepatocytes (CiHeps) exhibit comparable activity and function to primary hepatocytes, especially in liver repopulation to rescue liver failure in fumarylacetoacetate …
RNA sequencing analysis, metabolic assays, and in vivo physiological experiments show that chemically induced hepatocytes (CiHeps) exhibit c …
558 results