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1957 1
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Poloxamer 188 as surfactant in biological formulations - An alternative for polysorbate 20/80?
Bollenbach L, Buske J, Mäder K, Garidel P. Bollenbach L, et al. Int J Pharm. 2022 May 25;620:121706. doi: 10.1016/j.ijpharm.2022.121706. Epub 2022 Apr 1. Int J Pharm. 2022. PMID: 35367584 Review.
The search of alternatives with preferably less reservations concerning degradation and product quality reducing issues leads, among others, to poloxamer 188 (e.g. Kolliphor P188), a nonionic triblock-copolymer surfactant. This review sums up our current knowledge r …
The search of alternatives with preferably less reservations concerning degradation and product quality reducing issues leads, among others, …
Poloxamer 188 for Sickle Cell Disease.
Zylke J. Zylke J. JAMA. 2021 Apr 20;325(15):1524. doi: 10.1001/jama.2021.3399. JAMA. 2021. PMID: 33877286 No abstract available.
A review of poloxamer 407 pharmaceutical and pharmacological characteristics.
Dumortier G, Grossiord JL, Agnely F, Chaumeil JC. Dumortier G, et al. Pharm Res. 2006 Dec;23(12):2709-28. doi: 10.1007/s11095-006-9104-4. Epub 2006 Nov 11. Pharm Res. 2006. PMID: 17096184 Review.
Combination with other excipients like Poloxamer 188 or mucoadhesive polymers promotes Poloxamer 407 action by optimising sol-gel transition temperature or increasing bioadhesive properties. Inclusion of liposomes or micro(nano)particles in Poloxamer 4 …
Combination with other excipients like Poloxamer 188 or mucoadhesive polymers promotes Poloxamer 407 action by optimisi …
Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.
Casella JF, Barton BA, Kanter J, Black LV, Majumdar S, Inati A, Wali Y, Drachtman RA, Abboud MR, Kilinc Y, Fuh BR, Al-Khabori MK, Takemoto CM, Salman E, Sarnaik SA, Shah N, Morris CR, Keates-Baleeiro J, Raj A, Alvarez OA, Hsu LL, Thompson AA, Sisler IY, Pace BS, Noronha SA, Lasky JL 3rd, de Julian EC, Godder K, Thornburg CD, Kamberos NL, Nuss R, Marsh AM, Owen WC, Schaefer A, Tebbi CK, Chantrain CF, Cohen DE, Karakas Z, Piccone CM, George A, Fixler JM, Singleton TC, Moulton T, Quinn CT, de Castro Lobo CL, Almomen AM, Goyal-Khemka M, Maes P, Emanuele M, Gorney RT, Padgett CS, Parsley E, Kronsberg SS, Kato GJ, Gladwin MT. Casella JF, et al. JAMA. 2021 Apr 20;325(15):1513-1523. doi: 10.1001/jama.2021.3414. JAMA. 2021. PMID: 33877274 Free PMC article. Clinical Trial.
INTERVENTIONS: A 1-hour 100-mg/kg loading dose of poloxamer 188 intravenously followed by a 12-hour to 48-hour 30-mg/kg/h continuous infusion (n = 194) or placebo (n = 194). ...These findings do not support the use of poloxamer 188 for vaso-occlusive e …
INTERVENTIONS: A 1-hour 100-mg/kg loading dose of poloxamer 188 intravenously followed by a 12-hour to 48-hour 30-mg/kg/h cont …
Poloxamer(188)-based nanoparticles improve the anti-oxidation and anti-degradation of curcumin.
Hou X, Liang J, Yang X, Bai J, Yang M, Qiao N, Hu Z, Yan X, Shi Y. Hou X, et al. Food Chem. 2022 May 1;375:131674. doi: 10.1016/j.foodchem.2021.131674. Epub 2021 Nov 25. Food Chem. 2022. PMID: 34848087
But the shortcomings, such as poor water solubility, easy oxidation and degradation, limit its application. In this study, the CUR-loaded poloxamer(188)-based nanoparticles (CUR/PTT NPs) were fabricated to improve the stability and water solubility of CUR. ...
But the shortcomings, such as poor water solubility, easy oxidation and degradation, limit its application. In this study, the CUR-loaded …
Purified poloxamer 188 for sickle cell vaso-occlusive crisis.
Gibbs WJ, Hagemann TM. Gibbs WJ, et al. Ann Pharmacother. 2004 Feb;38(2):320-4. doi: 10.1345/aph.1D223. Epub 2003 Dec 30. Ann Pharmacother. 2004. PMID: 14742772 Review.
Key search terms included purified poloxamer 188, Flocor, CRL-5861, poloxamer 188, RheothRx, and pluronic F-68. ...DATA SYNTHESIS: Purified poloxamer 188 is a highly purified form of the nonionic block copolymer poloxamer 188 …
Key search terms included purified poloxamer 188, Flocor, CRL-5861, poloxamer 188, RheothRx, and pluronic F-68. …
Poloxamer 188 - quercetin formulations amplify in vitro ganciclovir antiviral activity against cytomegalovirus.
Kjar A, Wadsworth I, Vargis E, Britt DW. Kjar A, et al. Antiviral Res. 2022 Aug;204:105362. doi: 10.1016/j.antiviral.2022.105362. Epub 2022 Jun 13. Antiviral Res. 2022. PMID: 35709898
Here, combining GCV treatment with two bioactive excipients, poloxamer 188 and quercetin, was investigated in vitro to reduce GCV dosage. ...To overcome this challenge, quercetin was co-formulated with poloxamer 188 (P188, Pluronic F68). Quercetin-P188 …
Here, combining GCV treatment with two bioactive excipients, poloxamer 188 and quercetin, was investigated in vitro to reduce …
Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications.
Moloughney JG, Weisleder N. Moloughney JG, et al. Recent Pat Biotechnol. 2012 Dec;6(3):200-11. doi: 10.2174/1872208311206030200. Recent Pat Biotechnol. 2012. PMID: 23092436 Free PMC article. Review.
Efforts to find reagents that can modulate plasma membrane reseal found that specific tri-block copolymers, such as poloxamer 188 (P188, or Pluronic F68), can increase the structural stability and resealing of the plasma membrane. ...
Efforts to find reagents that can modulate plasma membrane reseal found that specific tri-block copolymers, such as poloxamer 188 …
Poloxamer-188 Exacerbates Brain Amyloidosis, Presynaptic Dystrophies, and Pathogenic Microglial Activation in 5XFAD Mice.
Di Meco A, Kemal S, Popovic J, Chandra S, Sadleir K, Vassar R. Di Meco A, et al. Curr Alzheimer Res. 2022;19(4):317-329. doi: 10.2174/1567205019666220509143823. Curr Alzheimer Res. 2022. PMID: 35579170 Free PMC article.
OBJECTIVE: We tested whether promoting membrane integrity by brain administration of a safe FDA approved surfactant molecule poloxamer-188 (P188) could attenuate AD pathology in vivo. METHODS: Three-month-old 5XFAD male mice were administered several concentrations …
OBJECTIVE: We tested whether promoting membrane integrity by brain administration of a safe FDA approved surfactant molecule poloxamer …
5,807 results

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