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Topical recombinant thrombin at a concentration of 1000 IU/mL reliably shortens in vivo TTH and delivers durable hemostasis in the presence of heparin anticoagulation and clopidogrel platelet inhibition in a rabbit model of vascular bleeding.
Hughes SD, Bishop PD, Garcia R, Zhang T, Alexander WA. Hughes SD, et al. Among authors: bishop pd. Ann Surg Innov Res. 2009 Nov 19;3:14. doi: 10.1186/1750-1164-3-14. Ann Surg Innov Res. 2009. PMID: 19925675 Free PMC article.
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