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Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Alexander WS, Starr R, Metcalf D, Nicholson SE, Farley A, Elefanty AG, Brysha M, Kile BT, Richardson R, Baca M, Zhang JG, Willson TA, Viney EM, Sprigg NS, Rakar S, Corbin J, Mifsud S, DiRago L, Cary D, Nicola NA, Hilton DJ. Alexander WS, et al. Among authors: farley a. J Leukoc Biol. 1999 Oct;66(4):588-92. doi: 10.1002/jlb.66.4.588. J Leukoc Biol. 1999. PMID: 10534114 Review.
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. Zhang JG, et al. Among authors: farley a. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2071-6. doi: 10.1073/pnas.96.5.2071. Proc Natl Acad Sci U S A. 1999. PMID: 10051596 Free PMC article.
Suckling defect in mice lacking the soluble haemopoietin receptor NR6.
Alexander WS, Rakar S, Robb L, Farley A, Willson TA, Zhang JG, Hartley L, Kikuchi Y, Kojima T, Nomura H, Hasegawa M, Maeda M, Fabri L, Jachno K, Nash A, Metcalf D, Nicola NA, Hilton DJ. Alexander WS, et al. Among authors: farley a. Curr Biol. 1999 Jun 3;9(11):605-8. doi: 10.1016/s0960-9822(99)80266-8. Curr Biol. 1999. PMID: 10359701 Free article.
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang JG, Silva A, Asimakis M, Farley A, Nash AD, Metcalf D, Hilton DJ, Nicola NA, Baca M. Nicholson SE, et al. Among authors: farley a. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6493-8. doi: 10.1073/pnas.100135197. Proc Natl Acad Sci U S A. 2000. PMID: 10829066 Free PMC article.
Negative regulation of cytokine signaling by the SOCS proteins.
Nicola NA, Nicholson SE, Metcalf D, Zhang JG, Baca M, Farley A, Willson TA, Starr R, Alexander W, Hilton DJ. Nicola NA, et al. Among authors: farley a. Cold Spring Harb Symp Quant Biol. 1999;64:397-404. doi: 10.1101/sqb.1999.64.397. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232314 Review. No abstract available.
Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. Zhang JG, et al. Among authors: farley a. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi: 10.1073/pnas.1507812112. Epub 2015 May 8. Proc Natl Acad Sci U S A. 2015. PMID: 25956176 Free PMC article. No abstract available.
Membrane budding is a major mechanism of in vivo platelet biogenesis.
Potts KS, Farley A, Dawson CA, Rimes J, Biben C, de Graaf C, Potts MA, Stonehouse OJ, Carmagnac A, Gangatirkar P, Josefsson EC, Anttila C, Amann-Zalcenstein D, Naik S, Alexander WS, Hilton DJ, Hawkins ED, Taoudi S. Potts KS, et al. Among authors: farley a. J Exp Med. 2020 Sep 7;217(9):e20191206. doi: 10.1084/jem.20191206. J Exp Med. 2020. PMID: 32706855 Free PMC article.
252 results