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Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity.
Benbrook DM, Madler MM, Spruce LW, Birckbichler PJ, Nelson EC, Subramanian S, Weerasekare GM, Gale JB, Patterson MK Jr, Wang B, Wang W, Lu S, Rowland TC, DiSivestro P, Lindamood C 3rd, Hill DL, Berlin KD. Benbrook DM, et al. Among authors: lu s. J Med Chem. 1997 Oct 24;40(22):3567-83. doi: 10.1021/jm970196m. J Med Chem. 1997. PMID: 9357524
Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells.
Simoni D, Roberti M, Invidiata FP, Rondanin R, Baruchello R, Malagutti C, Mazzali A, Rossi M, Grimaudo S, Capone F, Dusonchet L, Meli M, Raimondi MV, Landino M, D'Alessandro N, Tolomeo M, Arindam D, Lu S, Benbrook DM. Simoni D, et al. Among authors: lu s. J Med Chem. 2001 Jul 5;44(14):2308-18. doi: 10.1021/jm0010320. J Med Chem. 2001. PMID: 11428925
Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
Zheng CH, Yang H, Zhang M, Lu SH, Shi D, Wang J, Chen XH, Ren XH, Liu J, Lv JG, Zhu J, Zhou YJ. Zheng CH, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):39-44. doi: 10.1016/j.bmcl.2011.11.101. Epub 2011 Dec 1. Bioorg Med Chem Lett. 2012. PMID: 22172701
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