Misfolding of mutant aquaporin-2 water channels in nephrogenic diabetes insipidus.
Tamarappoo BK, Yang B, Verkman AS.
Tamarappoo BK, et al. Among authors: verkman as.
J Biol Chem. 1999 Dec 3;274(49):34825-31. doi: 10.1074/jbc.274.49.34825.
J Biol Chem. 1999.
PMID: 10574954
Free article.
We reported that several aquaporin-2 (AQP2) point mutants that cause nephrogenic diabetes insipidus (NDI) are retained in the endoplasmic reticulum (ER) of transfected mammalian cells and degraded but can be rescued by chemical chaperones to function as plasma membrane wat …
We reported that several aquaporin-2 (AQP2) point mutants that cause nephrogenic diabetes insipidus (NDI) are retained in the endoplasmic re …