Abdel-Meguid SS - Search Results

1

Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.

Qiu X, Janson CA, Konstantinidis AK, Nwagwu S, Silverman C, Smith WW, Khandekar S, Lonsdale J, Abdel-Meguid SS. Qiu X, et al. J Biol Chem. 1999 Dec 17;274(51):36465-71. doi: 10.1074/jbc.274.51.36465. J Biol Chem. 1999. PMID: 10593943 Free article.

2

Crystal structure of varicella-zoster virus protease.

Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS. Qiu X, et al. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. doi: 10.1073/pnas.94.7.2874. Proc Natl Acad Sci U S A. 1997. PMID: 9096314 Free PMC article.

3

Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex.

Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS. Hoog SS, et al. Biochemistry. 1997 Nov 18;36(46):14023-9. doi: 10.1021/bi9712697. Biochemistry. 1997. PMID: 9369473

4

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic.

Thompson SK, Smith WW, Zhao B, Halbert SM, Tomaszek TA, Tew DG, Levy MA, Janson CA, DAlessio KJ, McQueney MS, Kurdyla J, Jones CS, DesJarlais RL, Abdel-Meguid SS, Veber DF. Thompson SK, et al. J Med Chem. 1998 Oct 8;41(21):3923-7. doi: 10.1021/jm980474x. J Med Chem. 1998. PMID: 9767629

5

Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.

LaLonde JM, Zhao B, Smith WW, Janson CA, DesJarlais RL, Tomaszek TA, Carr TJ, Thompson SK, Oh HJ, Yamashita DS, Veber DF, Abdel-Meguid SS. LaLonde JM, et al. J Med Chem. 1998 Nov 5;41(23):4567-76. doi: 10.1021/jm980249f. J Med Chem. 1998. PMID: 9804696

6

Cooperative structural dynamics and a novel fidelity mechanism in histidyl-tRNA synthetases.

Qiu X, Janson CA, Blackburn MN, Chhohan IK, Hibbs M, Abdel-Meguid SS. Qiu X, et al. Biochemistry. 1999 Sep 21;38(38):12296-304. doi: 10.1021/bi990482v. Biochemistry. 1999. PMID: 10493797

7

Molecular basis for triclosan activity involves a flipping loop in the active site.

Qiu X, Janson CA, Court RI, Smyth MG, Payne DJ, Abdel-Meguid SS. Qiu X, et al. Protein Sci. 1999 Nov;8(11):2529-32. doi: 10.1110/ps.8.11.2529. Protein Sci. 1999. PMID: 10595560 Free PMC article.

8

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, Kikly K, Winkler JD, Sung CM, Debouck C, Richardson S, Levy MA, DeWolf WE Jr, Keller PM, Tomaszek T, Head MS, Ryan MD, Haltiwanger RC, Liang PH, Janson CA, McDevitt PJ, Johanson K, Concha NO, Chan W, Abdel-Meguid SS, Badger AM, Lark MW, Nadeau DP, Suva LJ, Gowen M, Nuttall ME. Lee D, et al. Among authors: abdel meguid ss. J Biol Chem. 2000 May 26;275(21):16007-14. doi: 10.1074/jbc.275.21.16007. J Biol Chem. 2000. PMID: 10821855 Free article.

9

Unique fold and active site in cytomegalovirus protease.

Qiu X, Culp JS, DiLella AG, Hellmig B, Hoog SS, Janson CA, Smith WW, Abdel-Meguid SS. Qiu X, et al. Nature. 1996 Sep 19;383(6597):275-9. doi: 10.1038/383275a0. Nature. 1996. PMID: 8805707

10

Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.

Marquis RW, Yamashita DS, Ru Y, LoCastro SM, Oh HJ, Erhard KF, DesJarlais RL, Head MS, Smith WW, Zhao B, Janson CA, Abdel-Meguid SS, Tomaszek TA, Levy MA, Veber DF. Marquis RW, et al. J Med Chem. 1998 Sep 10;41(19):3563-7. doi: 10.1021/jm980295f. J Med Chem. 1998. PMID: 9733481 No abstract available.

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