Levy OE - Search Results

1

Exploratory solid-phase synthesis of factor Xa inhibitors: discovery and application of p3-heterocyclic amides as novel types of non-basic arginine surrogates.

Ho JZ, Levy OE, Gibson TS, Nguyen K, Semple JE. Ho JZ, et al. Among authors: levy oe. Bioorg Med Chem Lett. 1999 Dec 20;9(24):3459-64. doi: 10.1016/s0960-894x(99)00628-9. Bioorg Med Chem Lett. 1999. PMID: 10617091

2

Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa.

Tamura SY, Levy OE, Uong TH, Reiner JE, Goldman EA, Ho JZ, Cohen CR, Bergum PW, Nutt RF, Brunck TK, Semple JE. Tamura SY, et al. Among authors: levy oe. Bioorg Med Chem Lett. 2000 Apr 17;10(8):745-9. doi: 10.1016/s0960-894x(00)00105-0. Bioorg Med Chem Lett. 2000. PMID: 10782677

3

New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction.

Semple JE, Owens TD, Nguyen K, Levy OE. Semple JE, et al. Among authors: levy oe. Org Lett. 2000 Sep 7;2(18):2769-72. doi: 10.1021/ol0061485. Org Lett. 2000. PMID: 10964361

4

Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties.

Semple JE, Levy OE, Minami NK, Owens TD, Siev DV. Semple JE, et al. Among authors: levy oe. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2305-9. doi: 10.1016/s0960-894x(00)00458-3. Bioorg Med Chem Lett. 2000. PMID: 11055344

5

Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.

Levy OE, Semple JE, Lim ML, Reiner J, Rote WE, Dempsey E, Richard BM, Zhang E, Tulinsky A, Ripka WC, Nutt RF. Levy OE, et al. J Med Chem. 1996 Nov 8;39(23):4527-30. doi: 10.1021/jm960607j. J Med Chem. 1996. PMID: 8917638 No abstract available.

6

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.

Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK. Krishnan R, et al. Among authors: levy oe. Biochemistry. 1998 Sep 1;37(35):12094-103. doi: 10.1021/bi980840e. Biochemistry. 1998. PMID: 9724521

7

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.

Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK. Arasappan A, et al. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. doi: 10.1016/j.bmcl.2005.06.091. Bioorg Med Chem Lett. 2005. PMID: 16087332

8

Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.

Bogen SL, Arasappan A, Bennett F, Chen K, Jao E, Liu YT, Lovey RG, Venkatraman S, Pan W, Parekh T, Pike RE, Ruan S, Liu R, Baroudy B, Agrawal S, Chase R, Ingravallo P, Pichardo J, Prongay A, Brisson JM, Hsieh TY, Cheng KC, Kemp SJ, Levy OE, Lim-Wilby M, Tamura SY, Saksena AK, Girijavallabhan V, Njoroge FG. Bogen SL, et al. Among authors: levy oe. J Med Chem. 2006 May 4;49(9):2750-7. doi: 10.1021/jm060077j. J Med Chem. 2006. PMID: 16640336

9

A mechanism-based inactivation study of neutral endopeptidase 24.11.

Levy OE, Taibi P, Mobashery S, Ghosh SS. Levy OE, et al. J Med Chem. 1993 Aug 6;36(16):2408-11. doi: 10.1021/jm00068a019. J Med Chem. 1993. PMID: 8360886

10

Crystal structure of the oligomerization domain of NSP4 from rotavirus reveals a core metal-binding site.

Bowman GD, Nodelman IM, Levy O, Lin SL, Tian P, Zamb TJ, Udem SA, Venkataraghavan B, Schutt CE. Bowman GD, et al. J Mol Biol. 2000 Dec 15;304(5):861-71. doi: 10.1006/jmbi.2000.4250. J Mol Biol. 2000. PMID: 11124032

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