Marnett LJ - Search Results

1

Structural insights into the stereochemistry of the cyclooxygenase reaction.

Kiefer JR, Pawlitz JL, Moreland KT, Stegeman RA, Hood WF, Gierse JK, Stevens AM, Goodwin DC, Rowlinson SW, Marnett LJ, Stallings WC, Kurumbail RG. Kiefer JR, et al. Among authors: marnett lj. Nature. 2000 May 4;405(6782):97-101. doi: 10.1038/35011103. Nature. 2000. PMID: 10811226

2

Cyclooxygenase enzymes: catalysis and inhibition.

Kurumbail RG, Kiefer JR, Marnett LJ. Kurumbail RG, et al. Among authors: marnett lj. Curr Opin Struct Biol. 2001 Dec;11(6):752-60. doi: 10.1016/s0959-440x(01)00277-9. Curr Opin Struct Biol. 2001. PMID: 11751058 Review.

3

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.

Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ. Rowlinson SW, et al. Among authors: marnett lj. J Biol Chem. 2003 Nov 14;278(46):45763-9. doi: 10.1074/jbc.M305481200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925531 Free article.

4

Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.

Rowlinson SW, Crews BC, Goodwin DC, Schneider C, Gierse JK, Marnett LJ. Rowlinson SW, et al. Among authors: marnett lj. J Biol Chem. 2000 Mar 3;275(9):6586-91. doi: 10.1074/jbc.275.9.6586. J Biol Chem. 2000. PMID: 10692466 Free article.

5

Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysis.

Goodwin DC, Rowlinson SW, Marnett LJ. Goodwin DC, et al. Among authors: marnett lj. Biochemistry. 2000 May 9;39(18):5422-32. doi: 10.1021/bi992752f. Biochemistry. 2000. PMID: 10820014

6

Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.

Kozak KR, Rowlinson SW, Marnett LJ. Kozak KR, et al. Among authors: marnett lj. J Biol Chem. 2000 Oct 27;275(43):33744-9. doi: 10.1074/jbc.M007088200. J Biol Chem. 2000. PMID: 10931854 Free article.

7

Mechanism of inhibition of novel COX-2 inhibitors.

Gierse J, Kurumbail R, Walker M, Hood B, Monahan J, Pawlitz J, Stegeman R, Stevens A, Kiefer J, Koboldt C, Moreland K, Rowlinson S, Marnett L, Pierce J, Carter J, Talley J, Isakson P, Seibert K. Gierse J, et al. Adv Exp Med Biol. 2002;507:365-9. doi: 10.1007/978-1-4615-0193-0_56. Adv Exp Med Biol. 2002. PMID: 12664611 No abstract available.

8

The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region.

Rowlinson SW, Crews BC, Lanzo CA, Marnett LJ. Rowlinson SW, et al. Among authors: marnett lj. J Biol Chem. 1999 Aug 13;274(33):23305-10. doi: 10.1074/jbc.274.33.23305. J Biol Chem. 1999. PMID: 10438506 Free article.

9

Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol.

Kozak KR, Prusakiewicz JJ, Rowlinson SW, Schneider C, Marnett LJ. Kozak KR, et al. Among authors: marnett lj. J Biol Chem. 2001 Aug 10;276(32):30072-7. doi: 10.1074/jbc.M104467200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402053 Free article.

10

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349.

Schneider C, Boeglin WE, Prusakiewicz JJ, Rowlinson SW, Marnett LJ, Samel N, Brash AR. Schneider C, et al. Among authors: marnett lj. J Biol Chem. 2002 Jan 4;277(1):478-85. doi: 10.1074/jbc.M107471200. Epub 2001 Oct 24. J Biol Chem. 2002. PMID: 11677234 Free article.

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