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Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature. 2000 May 4;405(6782):97-101. doi: 10.1038/35011103.
Nature. 2000.
PMID: 10811226
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ.
Rowlinson SW, et al. Among authors: pawlitz jl.
J Biol Chem. 2003 Nov 14;278(46):45763-9. doi: 10.1074/jbc.M305481200. Epub 2003 Aug 18.
J Biol Chem. 2003.
PMID: 12925531
Free article.
Item in Clipboard
Mechanism of inhibition of novel COX-2 inhibitors.
Gierse J, Kurumbail R, Walker M, Hood B, Monahan J, Pawlitz J, Stegeman R, Stevens A, Kiefer J, Koboldt C, Moreland K, Rowlinson S, Marnett L, Pierce J, Carter J, Talley J, Isakson P, Seibert K.
Gierse J, et al.
Adv Exp Med Biol. 2002;507:365-9. doi: 10.1007/978-1-4615-0193-0_56.
Adv Exp Med Biol. 2002.
PMID: 12664611
No abstract available.
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Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.
Graneto MJ, Kurumbail RG, Vazquez ML, Shieh HS, Pawlitz JL, Williams JM, Stallings WC, Geng L, Naraian AS, Koszyk FJ, Stealey MA, Xu XD, Weier RM, Hanson GJ, Mourey RJ, Compton RP, Mnich SJ, Anderson GD, Monahan JB, Devraj R.
Graneto MJ, et al. Among authors: pawlitz jl.
J Med Chem. 2007 Nov 15;50(23):5712-9. doi: 10.1021/jm0611915. Epub 2007 Oct 19.
J Med Chem. 2007.
PMID: 17948975
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The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate.
Wang JL, Carter J, Kiefer JR, Kurumbail RG, Pawlitz JL, Brown D, Hartmann SJ, Graneto MJ, Seibert K, Talley JJ.
Wang JL, et al. Among authors: pawlitz jl.
Bioorg Med Chem Lett. 2010 Dec 1;20(23):7155-8. doi: 10.1016/j.bmcl.2010.07.053. Epub 2010 Jul 23.
Bioorg Med Chem Lett. 2010.
PMID: 21055613
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The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life.
Wang JL, Limburg D, Graneto MJ, Springer J, Hamper JR, Liao S, Pawlitz JL, Kurumbail RG, Maziasz T, Talley JJ, Kiefer JR, Carter J.
Wang JL, et al. Among authors: pawlitz jl.
Bioorg Med Chem Lett. 2010 Dec 1;20(23):7159-63. doi: 10.1016/j.bmcl.2010.07.054. Epub 2010 Jul 24.
Bioorg Med Chem Lett. 2010.
PMID: 20709553
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