Li Q - Search Results

1

The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors.

Li Q, Mitscher LA, Shen LL. Li Q, et al. Med Res Rev. 2000 Jul;20(4):231-93. doi: 10.1002/1098-1128(200007)20:4<231::aid-med1>3.0.co;2-n. Med Res Rev. 2000. PMID: 10861727 Review.

2

Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.

Li Q, Chu DT, Claiborne A, Cooper CS, Lee CM, Raye K, Berst KB, Donner P, Wang W, Hasvold L, Fung A, Ma Z, Tufano M, Flamm R, Shen LL, Baranowski J, Nilius A, Alder J, Meulbroek J, Marsh K, Crowell D, Hui Y, Seif L, Melcher LM, Plattner JJ, et al. Li Q, et al. J Med Chem. 1996 Aug 2;39(16):3070-88. doi: 10.1021/jm960207w. J Med Chem. 1996. PMID: 8759628

3

Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.

Li Q, Wang W, Berst KB, Claiborne A, Hasvold L, Raye K, Tufano M, Nilius A, Shen LL, Flamm R, Alder J, Marsh K, Crowell D, Chu DT, Plattner JJ. Li Q, et al. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1953-8. doi: 10.1016/s0960-894x(98)00355-2. Bioorg Med Chem Lett. 1998. PMID: 9873465

4

Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.

Ma Z, Chu DT, Cooper CS, Li Q, Fung AK, Wang S, Shen LL, Flamm RK, Nilius AM, Alder JD, Meulbroek JA, Or YS. Ma Z, et al. Among authors: li q. J Med Chem. 1999 Oct 7;42(20):4202-13. doi: 10.1021/jm990191k. J Med Chem. 1999. PMID: 10514290

5

Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.

Hasvold LA, Wang W, Gwaltney SL 2nd, Rockway TW, Nelson LT, Mantei RA, Fakhoury SA, Sullivan GM, Li Q, Lin NH, Wang L, Zhang H, Cohen J, Gu WZ, Marsh K, Bauch J, Rosenberg S, Sham HL. Hasvold LA, et al. Among authors: li q. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4001-5. doi: 10.1016/j.bmcl.2003.08.058. Bioorg Med Chem Lett. 2003. PMID: 14592494

6

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.

Li Q, Claiborne A, Li T, Hasvold L, Stoll VS, Muchmore S, Jakob CG, Gu W, Cohen J, Hutchins C, Frost D, Rosenberg SH, Sham HL. Li Q, et al. Among authors: li t. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5367-70. doi: 10.1016/j.bmcl.2004.08.012. Bioorg Med Chem Lett. 2004. PMID: 15454228

7

In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor.

Flamm RK, Vojtko C, Chu DT, Li Q, Beyer J, Hensey D, Ramer N, Clement JJ, Tanaka SK. Flamm RK, et al. Among authors: li q. Antimicrob Agents Chemother. 1995 Apr;39(4):964-70. doi: 10.1128/AAC.39.4.964. Antimicrob Agents Chemother. 1995. PMID: 7786004 Free PMC article.

8

Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.

Zhu GD, Gong J, Gandhi VB, Woods K, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Stoll VS, Mamo M, Li Q, Rosenberg SH, Giranda VL. Zhu GD, et al. Among authors: li q. Bioorg Med Chem. 2007 Mar 15;15(6):2441-52. doi: 10.1016/j.bmc.2007.01.010. Epub 2007 Jan 17. Bioorg Med Chem. 2007. PMID: 17258463

9

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.

Szczepankiewicz BG, Liu G, Jae HS, Tasker AS, Gunawardana IW, von Geldern TW, Gwaltney SL 2nd, Wu-Wong JR, Gehrke L, Chiou WJ, Credo RB, Alder JD, Nukkala MA, Zielinski NA, Jarvis K, Mollison KW, Frost DJ, Bauch JL, Hui YH, Claiborne AK, Li Q, Rosenberg SH. Szczepankiewicz BG, et al. Among authors: li q. J Med Chem. 2001 Dec 6;44(25):4416-30. doi: 10.1021/jm010231w. J Med Chem. 2001. PMID: 11728187

10

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.

Woods KW, Fischer JP, Claiborne A, Li T, Thomas SA, Zhu GD, Diebold RB, Liu X, Shi Y, Klinghofer V, Han EK, Guan R, Magnone SR, Johnson EF, Bouska JJ, Olson AM, de Jong R, Oltersdorf T, Luo Y, Rosenberg SH, Giranda VL, Li Q. Woods KW, et al. Among authors: li t, li q. Bioorg Med Chem. 2006 Oct 15;14(20):6832-46. doi: 10.1016/j.bmc.2006.06.047. Epub 2006 Jul 14. Bioorg Med Chem. 2006. PMID: 16843670

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