Hirst W - Search Results

1

Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.

Routledge C, Bromidge SM, Moss SF, Price GW, Hirst W, Newman H, Riley G, Gager T, Stean T, Upton N, Clarke SE, Brown AM, Middlemiss DN. Routledge C, et al. Among authors: hirst w. Br J Pharmacol. 2000 Aug;130(7):1606-12. doi: 10.1038/sj.bjp.0703457. Br J Pharmacol. 2000. PMID: 10928964 Free PMC article.

2

Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist.

Stean TO, Hirst WD, Thomas DR, Price GW, Rogers D, Riley G, Bromidge SM, Serafinowska HT, Smith DR, Bartlett S, Deeks N, Duxon M, Upton N. Stean TO, et al. Among authors: hirst wd. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54. doi: 10.1016/s0091-3057(01)00742-0. Pharmacol Biochem Behav. 2002. PMID: 11888556

3

SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N. Hirst WD, et al. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19. doi: 10.1016/j.ejphar.2006.09.049. Epub 2006 Sep 29. Eur J Pharmacol. 2006. PMID: 17069795

4

Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue.

Hirst WD, Minton JA, Bromidge SM, Moss SF, Latter AJ, Riley G, Routledge C, Middlemiss DN, Price GW. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605. doi: 10.1038/sj.bjp.0703458. Br J Pharmacol. 2000. PMID: 10928963 Free PMC article.

5

Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.

Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ. Langmead CJ, et al. Among authors: hirst wd. Br J Pharmacol. 2000 Oct;131(4):683-8. doi: 10.1038/sj.bjp.0703617. Br J Pharmacol. 2000. PMID: 11030716 Free PMC article.

6

Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling.

Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD. Hirst WD, et al. Mol Pharmacol. 2003 Dec;64(6):1295-308. doi: 10.1124/mol.64.6.1295. Mol Pharmacol. 2003. PMID: 14645659

7

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models.

Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, Gonzalez MI, Heslop T, Hirst WD, Jennings C, Jones DN, Lacroix LP, Martyn A, Ociepka S, Ray A, Regan CM, Roberts JC, Schogger J, Southam E, Stean TO, Trail BK, Upton N, Wadsworth G, Wald JA, White T, Witherington J, Woolley ML, Worby A, Wilson DM. Medhurst AD, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45. doi: 10.1124/jpet.107.120311. Epub 2007 Feb 27. J Pharmacol Exp Ther. 2007. PMID: 17327487

8

Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes.

Hirst WD, Price GW, Rattray M, Wilkin GP. Hirst WD, et al. Br J Pharmacol. 1997 Feb;120(3):509-15. doi: 10.1038/sj.bjp.0700921. Br J Pharmacol. 1997. PMID: 9031757 Free PMC article.

9

The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.

Wood MD, Murkitt KL, Rice SQ, Testa T, Punia PK, Stammers M, Jenkins O, Elshourbagy NA, Shabon U, Taylor SJ, Gager TL, Minton J, Hirst WD, Price GW, Pangalos M. Wood MD, et al. Among authors: hirst wd. Br J Pharmacol. 2000 Nov;131(6):1050-4. doi: 10.1038/sj.bjp.0703682. Br J Pharmacol. 2000. PMID: 11082110 Free PMC article.

10

Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan.

Read SJ, Hirst WD, Upton N, Parsons AA. Read SJ, et al. Among authors: hirst wd. Brain Res. 2001 Feb 9;891(1-2):69-77. doi: 10.1016/s0006-8993(00)03191-7. Brain Res. 2001. PMID: 11164810

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