Haigh D - Search Results

1

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

Coghlan MP, Culbert AA, Cross DA, Corcoran SL, Yates JW, Pearce NJ, Rausch OL, Murphy GJ, Carter PS, Roxbee Cox L, Mills D, Brown MJ, Haigh D, Ward RW, Smith DG, Murray KJ, Reith AD, Holder JC. Coghlan MP, et al. Among authors: haigh d. Chem Biol. 2000 Oct;7(10):793-803. doi: 10.1016/s1074-5521(00)00025-9. Chem Biol. 2000. PMID: 11033082

2

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

Smith DG, Buffet M, Fenwick AE, Haigh D, Ife RJ, Saunders M, Slingsby BP, Stacey R, Ward RW. Smith DG, et al. Among authors: haigh d. Bioorg Med Chem Lett. 2001 Mar 12;11(5):635-9. doi: 10.1016/s0960-894x(00)00721-6. Bioorg Med Chem Lett. 2001. PMID: 11266159

3

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Witherington J, Bordas V, Haigh D, Hickey DM, Ife RJ, Rawlings AD, Slingsby BP, Smith DG, Ward RW. Witherington J, et al. Among authors: haigh d. Bioorg Med Chem Lett. 2003 May 5;13(9):1581-4. doi: 10.1016/s0960-894x(03)00135-5. Bioorg Med Chem Lett. 2003. PMID: 12699760

4

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.

Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA. Young PW, et al. Among authors: haigh d. J Pharmacol Exp Ther. 1998 Feb;284(2):751-9. J Pharmacol Exp Ther. 1998. PMID: 9454824

5

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

Smith DG, Gribble AD, Haigh D, Ife RJ, Lavery P, Skett P, Slingsby BP, Stacey R, Ward RW, West A. Smith DG, et al. Among authors: haigh d. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3137-42. doi: 10.1016/s0960-894x(99)00539-9. Bioorg Med Chem Lett. 1999. PMID: 10560740

6

Non-thiazolidinedione antihyperglycaemic agents. Part 3: The effects of stereochemistry on the potency of alpha-methoxy-beta-phenylpropanoic acids.

Haigh D, Allen G, Birrell HC, Buckle DR, Cantello BC, Eggleston DS, Haltiwanger RC, Holder JC, Lister CA, Pinto IL, Rami HK, Sime JT, Smith SA, Sweeney JD. Haigh D, et al. Bioorg Med Chem. 1999 May;7(5):821-30. doi: 10.1016/s0968-0896(99)00034-6. Bioorg Med Chem. 1999. PMID: 10400335

7

[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents.

Cantello BC, Cawthorne MA, Cottam GP, Duff PT, Haigh D, Hindley RM, Lister CA, Smith SA, Thurlby PL. Cantello BC, et al. Among authors: haigh d. J Med Chem. 1994 Nov 11;37(23):3977-85. doi: 10.1021/jm00049a017. J Med Chem. 1994. PMID: 7966158

8

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.

Burton G, Ku TW, Carr TJ, Kiesow T, Sarisky RT, Lin-Goerke J, Hofmann GA, Slater MJ, Haigh D, Dhanak D, Johnson VK, Parry NR, Thommes P. Burton G, et al. Among authors: haigh d. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1930-3. doi: 10.1016/j.bmcl.2007.01.034. Epub 2007 Jan 19. Bioorg Med Chem Lett. 2007. PMID: 17270443

9

Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library.

Donaldson LR, Wallace S, Haigh D, Patton EE, Hulme AN. Donaldson LR, et al. Among authors: haigh d. Org Biomol Chem. 2011 Apr 7;9(7):2233-9. doi: 10.1039/c0ob00449a. Epub 2011 Feb 7. Org Biomol Chem. 2011. PMID: 21298172 Free article.

10

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.

Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Jaye MC, et al. Among authors: haigh d. J Med Chem. 2005 Aug 25;48(17):5419-22. doi: 10.1021/jm050532w. J Med Chem. 2005. PMID: 16107141

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