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HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain.
Jorge R, Zarich N, Oliva JL, Azañedo M, Martínez N, de la Cruz X, Rojas JM. Jorge R, et al. Among authors: oliva jl. J Biol Chem. 2002 Nov 15;277(46):44171-9. doi: 10.1074/jbc.M204423200. Epub 2002 Sep 9. J Biol Chem. 2002. Retraction in: J Biol Chem. 2018 Jul 20;293(29):11650. doi: 10.1074/jbc.W118.004643. PMID: 12223473 Free article. Retracted.
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
Oliva JL, Zarich N, Martínez N, Jorge R, Castrillo A, Azañedo M, García-Vargas S, Gutiérrez-Eisman S, Juarranz A, Boscá L, Gutkind JS, Rojas JM. Oliva JL, et al. J Biol Chem. 2004 Aug 6;279(32):33480-91. doi: 10.1074/jbc.M404058200. Epub 2004 Jun 4. J Biol Chem. 2004. Retraction in: J Biol Chem. 2018 Jul 20;293(29):11651. doi: 10.1074/jbc.W118.004644. PMID: 15181015 Free article. Retracted.
Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1.
Zarich N, Oliva JL, Martínez N, Jorge R, Ballester A, Gutiérrez-Eisman S, García-Vargas S, Rojas JM. Zarich N, et al. Among authors: oliva jl. Mol Biol Cell. 2006 Aug;17(8):3591-7. doi: 10.1091/mbc.e05-12-1104. Epub 2006 Jun 7. Mol Biol Cell. 2006. PMID: 16760435 Free PMC article.
69 results