The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress.
Ciechanover A, Gropper R, Schwartz AL.
Ciechanover A, et al.
Biomed Biochim Acta. 1991;50(4-6):321-32.
Biomed Biochim Acta. 1991.
PMID: 1801698
ts85, a cell-line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short-lived proteins at the restrictive temperature (Ciechanover, A., Finley, D., and Varshavsky, A. (1984) Cell 37, 57-66). ...Analogous resu …
ts85, a cell-line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short-lived proteins at …