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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.
Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. doi: 10.1016/s0960-894x(01)00078-6.
Bioorg Med Chem Lett. 2001.
PMID: 11294386
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
Macdonald SJ, Dowle MD, Harrison LA, Clarke GD, Inglis GG, Johnson MR, Shah P, Smith RA, Amour A, Fleetwood G, Humphreys DC, Molloy CR, Dixon M, Godward RE, Wonacott AJ, Singh OM, Hodgson ST, Hardy GW.
Macdonald SJ, et al. Among authors: godward re.
J Med Chem. 2002 Aug 29;45(18):3878-90. doi: 10.1021/jm020881f.
J Med Chem. 2002.
PMID: 12190311
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Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.
Macdonald SJ, Dowle MD, Harrison LA, Spooner JE, Shah P, Johnson MR, Inglis GG, Clarke GD, Belton DJ, Smith RA, Molloy CR, Dixon M, Murkitt G, Godward RE, Skarzynski T, Singh OM, Kumar KA, Hodgson ST, McDonald E, Hardy GW, Finch H, Humphreys DC, Fleetwood G.
Macdonald SJ, et al. Among authors: godward re.
Bioorg Med Chem Lett. 2001 Jan 22;11(2):243-6. doi: 10.1016/s0960-894x(00)00632-6.
Bioorg Med Chem Lett. 2001.
PMID: 11206469
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The determination in human plasma of 1-hydroxy-2-naphthoic acid following administration of salmeterol xinafoate.
Chilton AS, Godward RE, Carey PF.
Chilton AS, et al. Among authors: godward re.
J Pharm Biomed Anal. 1995 Feb;13(2):165-9. doi: 10.1016/0731-7085(94)00122-i.
J Pharm Biomed Anal. 1995.
PMID: 7766724
Clinical Trial.
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Combined use of an automated sample processor and a polymer-based high-performance liquid chromatographic column to determine the pharmacokinetics of labetalol in man.
Bates J, Carey PF, Godward RE.
Bates J, et al. Among authors: godward re.
J Chromatogr. 1987 Jun 12;395:455-61. doi: 10.1016/s0021-9673(01)94132-9.
J Chromatogr. 1987.
PMID: 3624360
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