Fegan C - Search Results

1

Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia.

Pepper C, Thomas A, Hoy T, Fegan C, Bentley P. Pepper C, et al. Among authors: fegan c. Br J Haematol. 2001 Jul;114(1):70-7. doi: 10.1046/j.1365-2141.2001.02895.x. Br J Haematol. 2001. PMID: 11472347 Free article.

2

Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells.

Hamilton E, Pearce L, Morgan L, Robinson S, Ware V, Brennan P, Thomas NS, Yallop D, Devereux S, Fegan C, Buggins AG, Pepper C. Hamilton E, et al. Among authors: fegan c. Br J Haematol. 2012 Sep;158(5):589-99. doi: 10.1111/j.1365-2141.2012.09191.x. Epub 2012 Jun 19. Br J Haematol. 2012. PMID: 22712573 Free article.

3

Retinoid-induced apoptosis in B-cell chronic lymphocytic leukaemia cells is mediated through caspase-3 activation and is independent of p53, the retinoic acid receptor, and differentiation.

Pepper C, Ali K, Thomas A, Hoy T, Fegan C, Chowdary P, Kell J, Bentley P. Pepper C, et al. Among authors: fegan c. Eur J Haematol. 2002 Oct;69(4):227-35. doi: 10.1034/j.1600-0609.2002.02799.x. Eur J Haematol. 2002. PMID: 12431242

4

The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro.

Pepper C, Thomas A, Hoy T, Milligan D, Bentley P, Fegan C. Pepper C, et al. Among authors: fegan c. Blood. 2003 Apr 1;101(7):2454-60. doi: 10.1182/blood-2002-07-1984. Epub 2002 Nov 21. Blood. 2003. PMID: 12446453 Free article.

5

Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.

Pepper C, Thomas A, Fegan C, Hoy T, Bentley P. Pepper C, et al. Among authors: fegan c. Leuk Lymphoma. 2003 Feb;44(2):337-42. doi: 10.1080/1042819021000029984. Leuk Lymphoma. 2003. PMID: 12688354

6

Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.

Pepper C, Thomas A, Hoy T, Tighe J, Culligan D, Fegan C, Bentley P. Pepper C, et al. Among authors: fegan c. Cell Cycle. 2003 Jan-Feb;2(1):53-8. Cell Cycle. 2003. PMID: 12695689

7

Highly purified CD38 sub-populations show no evidence of preferential clonal evolution despite having increased proliferative activity when compared with CD38 sub-populations derived from the same chronic lymphocytic leukaemia patient.

Lin TT, Hewamana S, Ward R, Taylor H, Payne T, Pratt G, Baird D, Fegan C, Pepper C. Lin TT, et al. Among authors: fegan c. Br J Haematol. 2008 Aug;142(4):595-605. doi: 10.1111/j.1365-2141.2008.07236.x. Epub 2008 May 22. Br J Haematol. 2008. PMID: 18503580 Free article.

8

The P2X7 receptor gene polymorphism 1513 A-->C has no effect on clinical prognostic markers, in vitro sensitivity to fludarabine, Bcl-2 family protein expression or survival in B-cell chronic lymphocytic leukaemia.

Starczynski J, Pepper C, Pratt G, Hooper L, Thomas A, Hoy T, Milligan D, Bentley P, Fegan C. Starczynski J, et al. Among authors: fegan c. Br J Haematol. 2003 Oct;123(1):66-71. doi: 10.1046/j.1365-2141.2003.04563.x. Br J Haematol. 2003. PMID: 14510944 Free article.

9

The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.

Pepper CJ, Hambly RM, Fegan CD, Delavault P, Thurston DE. Pepper CJ, et al. Cancer Res. 2004 Sep 15;64(18):6750-5. doi: 10.1158/0008-5472.CAN-04-1713. Cancer Res. 2004. PMID: 15374993

10

Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate.

Delgado J, Pratt G, Phillips N, Briones J, Fegan C, Nomdedeu J, Pepper C, Aventin A, Ayats R, Brunet S, Martino R, Valcarcel D, Milligan D, Sierra J. Delgado J, et al. Among authors: fegan c. Br J Haematol. 2009 Jun;145(6):801-5. doi: 10.1111/j.1365-2141.2009.07699.x. Epub 2009 Apr 15. Br J Haematol. 2009. PMID: 19388937 Free article.

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