Krogsgaard-Larsen P - Search Results

1

Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.

Johansen TN, Stensbøl TB, Nielsen B, Vogensen SB, Frydenvang K, Sløk FA, Bräüner-Osborne H, Madsen U, Krogsgaard-Larsen P. Johansen TN, et al. Chirality. 2001;13(9):523-32. doi: 10.1002/chir.1172. Chirality. 2001. PMID: 11579444

2

Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.

Kromann H, Sløk FA, Stensbøl TB, Bräuner-Osborne H, Madsen U, Krogsgaard-Larsen P. Kromann H, et al. J Med Chem. 2002 Feb 14;45(4):988-91. doi: 10.1021/jm010443t. J Med Chem. 2002. PMID: 11831912

3

Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.

Guldbrandt M, Johansen TN, Frydenvang K, Bräuner-Osborne H, Stensbøl TB, Nielsen B, Karla R, Santi F, Krogsgaard-Larsen P, Madsen U. Guldbrandt M, et al. Chirality. 2002 May 5;14(4):351-63. doi: 10.1002/chir.10104. Chirality. 2002. PMID: 11968078

4

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors.

Johansen TN, Janin YL, Nielsen B, Frydenvang K, Bräuner-Osborne H, Stensbøl TB, Vogensen SB, Madsen U, Krogsgaard-Larsen P. Johansen TN, et al. Bioorg Med Chem. 2002 Jul;10(7):2259-66. doi: 10.1016/s0968-0896(02)00041-x. Bioorg Med Chem. 2002. PMID: 11983523

5

Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.

Clausen RP, Bräuner-Osborne H, Greenwood JR, Hermit MB, Stensbøl TB, Nielsen B, Krogsgaard-Larsen P. Clausen RP, et al. J Med Chem. 2002 Sep 12;45(19):4240-5. doi: 10.1021/jm020122x. J Med Chem. 2002. PMID: 12213064

6

Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.

Johansen TN, Greenwood JR, Frydenvang K, Madsen U, Krogsgaard-Larsen P. Johansen TN, et al. Chirality. 2003 Feb;15(2):167-79. doi: 10.1002/chir.10177. Chirality. 2003. PMID: 12520509 Review.

7

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

Brehm L, Greenwood JR, Hansen KB, Nielsen B, Egebjerg J, Stensbøl TB, Bräuner-Osborne H, Sløk FA, Kronborg TT, Krogsgaard-Larsen P. Brehm L, et al. J Med Chem. 2003 Apr 10;46(8):1350-8. doi: 10.1021/jm0204441. J Med Chem. 2003. PMID: 12672235

8

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen SB, Greenwood JR, Varming AR, Brehm L, Pickering DS, Nielsen B, Liljefors T, Clausen RP, Johansen TN, Krogsgaard-Larsen P. Vogensen SB, et al. Org Biomol Chem. 2004 Jan 21;2(2):206-13. doi: 10.1039/b310450h. Epub 2003 Nov 24. Org Biomol Chem. 2004. PMID: 14737644

9

Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.

Hermit MB, Greenwood JR, Nielsen B, Bunch L, Jørgensen CG, Vestergaard HT, Stensbøl TB, Sanchez C, Krogsgaard-Larsen P, Madsen U, Bräuner-Osborne H. Hermit MB, et al. Eur J Pharmacol. 2004 Feb 23;486(3):241-50. doi: 10.1016/j.ejphar.2003.12.033. Eur J Pharmacol. 2004. PMID: 14985045

10

Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.

Brehm L, Greenwood JR, Sløk FA, Holm MM, Nielsen B, Geneser U, Stensbøl TB, Bräuner-Osborne H, Begtrup M, Egebjerg J, Krogsgaard-Larsen P. Brehm L, et al. Chirality. 2004 Aug;16(7):452-66. doi: 10.1002/chir.20060. Chirality. 2004. PMID: 15236343

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