Olsson T - Search Results

1

Statistical molecular design, parallel synthesis, and biological evaluation of a library of thrombin inhibitors.

Linusson A, Gottfries J, Olsson T, Ornskov E, Folestad S, Nordén B, Wold S. Linusson A, et al. Among authors: olsson t. J Med Chem. 2001 Oct 11;44(21):3424-39. doi: 10.1021/jm010833f. J Med Chem. 2001. PMID: 11585448

2

Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A.

Wehrli PM, Uzelac I, Olsson T, Jacso T, Tietze D, Gottfries J. Wehrli PM, et al. Among authors: olsson t. Bioorg Med Chem. 2019 Oct 1;27(19):115043. doi: 10.1016/j.bmc.2019.115043. Epub 2019 Aug 7. Bioorg Med Chem. 2019. PMID: 31420255

3

Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa).

Brink M, Dahlén A, Olsson T, Polla M, Svensson T. Brink M, et al. Among authors: olsson t. Bioorg Med Chem. 2014 Apr 1;22(7):2261-8. doi: 10.1016/j.bmc.2014.02.010. Epub 2014 Feb 18. Bioorg Med Chem. 2014. PMID: 24588961

4

Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.

Chen H, Knerr L, Åkerud T, Hallberg K, Öster L, Rohman M, Österlund K, Beisel HG, Olsson T, Brengdhal J, Sandmark J, Bodin C. Chen H, et al. Among authors: olsson t. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5251-5. doi: 10.1016/j.bmcl.2014.09.058. Epub 2014 Sep 30. Bioorg Med Chem Lett. 2014. PMID: 25316315

5

Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.

Fjellström O, Akkaya S, Beisel HG, Eriksson PO, Erixon K, Gustafsson D, Jurva U, Kang D, Karis D, Knecht W, Nerme V, Nilsson I, Olsson T, Redzic A, Roth R, Sandmark J, Tigerström A, Öster L. Fjellström O, et al. Among authors: olsson t. PLoS One. 2015 Jan 28;10(1):e0113705. doi: 10.1371/journal.pone.0113705. eCollection 2015. PLoS One. 2015. PMID: 25629509 Free PMC article.

6

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A₂ Type X (sPLA₂-X) Inhibitors.

Knerr L, Giordanetto F, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Olsson T, Perkins TDJ, Herslöf M, Månsson Å, Dahlström M, Starke I, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Brengdahl J, Jansen F, Rohman M, Sandmark J, Hallberg K, Åkerud T, Roth RG, Ahlqvist M. Knerr L, et al. Among authors: olsson t. ACS Med Chem Lett. 2018 Jun 23;9(7):594-599. doi: 10.1021/acsmedchemlett.7b00505. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034585 Free PMC article.

7

Cheminformatics: a tool for decision-makers in drug discovery.

Olsson T, Oprea TI. Olsson T, et al. Curr Opin Drug Discov Devel. 2001 May;4(3):308-13. Curr Opin Drug Discov Devel. 2001. PMID: 11560063 Review.

8

Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration.

Xue Y, Olsson T, Johansson CA, Öster L, Beisel HG, Rohman M, Karis D, Bäckström S. Xue Y, et al. Among authors: olsson t. ChemMedChem. 2016 Mar 4;11(5):497-508. doi: 10.1002/cmdc.201500575. Epub 2016 Feb 4. ChemMedChem. 2016. PMID: 26845235

9

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.

Lincoln MR, Connally N, Axisa PP, Gasperi C, Mitrovic M, van Heel D, Wijmenga C, Withoff S, Jonkers IH, Padyukov L; International Multiple Sclerosis Genetics Consortium; Rich SS, Graham RR, Gaffney PM, Langefeld CD, Vyse TJ, Hafler DA, Chun S, Sunyaev SR, Cotsapas C. Lincoln MR, et al. Nat Genet. 2024 May;56(5):838-845. doi: 10.1038/s41588-024-01732-8. Epub 2024 May 13. Nat Genet. 2024. PMID: 38741015

10

Acute Hyperglycemia Induced by Hyperglycemic Clamp Affects Plasma Amyloid-β in Type 2 Diabetes.

Rolandsson O, Tornevi A, Steneberg P, Edlund H, Olsson T, Andreasson U, Zetterberg H, Blennow K. Rolandsson O, et al. Among authors: olsson t. J Alzheimers Dis. 2024;99(3):1033-1046. doi: 10.3233/JAD-230628. J Alzheimers Dis. 2024. PMID: 38728183 Clinical Trial.

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