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Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts.
Lin N, Sato T, Ito A. Lin N, et al. Among authors: sato t. Arthritis Rheum. 2001 Sep;44(9):2193-200. doi: 10.1002/1529-0131(200109)44:9<2193::aid-art373>3.0.co;2-5. Arthritis Rheum. 2001. PMID: 11592385 Free article.
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.
Tamura T, Kosaka N, Ishiwa J, Sato T, Nagase H, Ito A. Tamura T, et al. Among authors: sato t. Osteoarthritis Cartilage. 2001 Apr;9(3):257-63. doi: 10.1053/joca.2000.0383. Osteoarthritis Cartilage. 2001. PMID: 11300749 Free article.
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