Lao DH - Search Results

1

Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.

Yusoff P, Lao DH, Ong SH, Wong ES, Lim J, Lo TL, Leong HF, Fong CW, Guy GR. Yusoff P, et al. Among authors: lao dh. J Biol Chem. 2002 Feb 1;277(5):3195-201. doi: 10.1074/jbc.M108368200. Epub 2001 Nov 6. J Biol Chem. 2002. PMID: 11698404 Free article.

2

The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.

Lim J, Yusoff P, Wong ES, Chandramouli S, Lao DH, Fong CW, Guy GR. Lim J, et al. Among authors: lao dh. Mol Cell Biol. 2002 Nov;22(22):7953-66. doi: 10.1128/MCB.22.22.7953-7966.2002. Mol Cell Biol. 2002. PMID: 12391162 Free PMC article.

3

A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation.

Lao DH, Chandramouli S, Yusoff P, Fong CW, Saw TY, Tai LP, Yu CY, Leong HF, Guy GR. Lao DH, et al. J Biol Chem. 2006 Oct 6;281(40):29993-30000. doi: 10.1074/jbc.M604044200. Epub 2006 Aug 7. J Biol Chem. 2006. PMID: 16893902 Free article.

4

Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation.

Lao DH, Yusoff P, Chandramouli S, Philp RJ, Fong CW, Jackson RA, Saw TY, Yu CY, Guy GR. Lao DH, et al. J Biol Chem. 2007 Mar 23;282(12):9117-26. doi: 10.1074/jbc.M607563200. Epub 2007 Jan 25. J Biol Chem. 2007. PMID: 17255109 Free article.

5

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

Chandramouli S, Yu CY, Yusoff P, Lao DH, Leong HF, Mizuno K, Guy GR. Chandramouli S, et al. Among authors: lao dh. J Biol Chem. 2008 Jan 18;283(3):1679-1691. doi: 10.1074/jbc.M705457200. Epub 2007 Nov 1. J Biol Chem. 2008. PMID: 17974561 Free article.

6

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.

Yan J, Mei FC, Cheng H, Lao DH, Hu Y, Wei J, Patrikeev I, Hao D, Stutz SJ, Dineley KT, Motamedi M, Hommel JD, Cunningham KA, Chen J, Cheng X. Yan J, et al. Among authors: lao dh. Mol Cell Biol. 2013 Mar;33(5):918-26. doi: 10.1128/MCB.01227-12. Epub 2012 Dec 21. Mol Cell Biol. 2013. PMID: 23263987 Free PMC article.

7

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. Pereira L, et al. Among authors: lao dh. Circulation. 2013 Feb 26;127(8):913-22. doi: 10.1161/CIRCULATIONAHA.12.148619. Epub 2013 Jan 30. Circulation. 2013. PMID: 23363625 Free PMC article.

8

Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.

Pereira L, Rehmann H, Lao DH, Erickson JR, Bossuyt J, Chen J, Bers DM. Pereira L, et al. Among authors: lao dh. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):3991-6. doi: 10.1073/pnas.1416163112. Epub 2015 Mar 17. Proc Natl Acad Sci U S A. 2015. PMID: 25829540 Free PMC article.

9

Lmo7 is dispensable for skeletal muscle and cardiac function.

Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton KU, Peterson KL, Lieber RL, Chen J. Lao DH, et al. Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C470-9. doi: 10.1152/ajpcell.00177.2015. Epub 2015 Jul 8. Am J Physiol Cell Physiol. 2015. PMID: 26157009 Free PMC article.

10

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.

Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Fang X, et al. Among authors: lao dh. J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737513 Free PMC article.

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