Fukasawa K - Search Results

1

A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.

Honma T, Yoshizumi T, Hashimoto N, Hayashi K, Kawanishi N, Fukasawa K, Takaki T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: fukasawa k. J Med Chem. 2001 Dec 20;44(26):4628-40. doi: 10.1021/jm010326y. J Med Chem. 2001. PMID: 11741480

2

Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.

Ikuta M, Kamata K, Fukasawa K, Honma T, Machida T, Hirai H, Suzuki-Takahashi I, Hayama T, Nishimura S. Ikuta M, et al. Among authors: fukasawa k. J Biol Chem. 2001 Jul 20;276(29):27548-54. doi: 10.1074/jbc.M102060200. Epub 2001 May 2. J Biol Chem. 2001. PMID: 11335721 Free article.

3

Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.

Honma T, Hayashi K, Aoyama T, Hashimoto N, Machida T, Fukasawa K, Iwama T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Iwasawa Y, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: fukasawa k. J Med Chem. 2001 Dec 20;44(26):4615-27. doi: 10.1021/jm0103256. J Med Chem. 2001. PMID: 11741479

4

Cdk-mediated phosphorylation of pRB regulates HDAC binding in vitro.

Takaki T, Fukasawa K, Suzuki-Takahashi I, Hirai H. Takaki T, et al. Among authors: fukasawa k. Biochem Biophys Res Commun. 2004 Mar 26;316(1):252-5. doi: 10.1016/j.bbrc.2004.02.044. Biochem Biophys Res Commun. 2004. PMID: 15003538

5

Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro.

Takaki T, Fukasawa K, Suzuki-Takahashi I, Semba K, Kitagawa M, Taya Y, Hirai H. Takaki T, et al. Among authors: fukasawa k. J Biochem. 2005 Mar;137(3):381-6. doi: 10.1093/jb/mvi050. J Biochem. 2005. PMID: 15809340

6

Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo.

Hirai H, Shimomura T, Kobayashi M, Eguchi T, Taniguchi E, Fukasawa K, Machida T, Oki H, Arai T, Ichikawa K, Hasako S, Haze K, Kodera T, Kawanishi N, Takahashi-Suziki I, Nakatsuru Y, Kotani H, Iwasawa Y. Hirai H, et al. Among authors: fukasawa k. Cell Cycle. 2010 Apr 15;9(8):1590-600. doi: 10.4161/cc.9.8.11306. Epub 2010 Apr 15. Cell Cycle. 2010. PMID: 20372067

7

Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo.

Hirai H, Takahashi-Suziki I, Shimomura T, Fukasawa K, Machida T, Takaki T, Kobayashi M, Eguchi T, Oki H, Arai T, Ichikawa K, Hasako S, Kodera T, Kawanishi N, Nakatsuru Y, Kotani H, Iwasawa Y. Hirai H, et al. Among authors: fukasawa k. Invest New Drugs. 2011 Aug;29(4):534-43. doi: 10.1007/s10637-009-9384-8. Epub 2010 Jan 19. Invest New Drugs. 2011. PMID: 20084424

8

Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding.

Takimura T, Kamata K, Fukasawa K, Ohsawa H, Komatani H, Yoshizumi T, Takahashi I, Kotani H, Iwasawa Y. Takimura T, et al. Among authors: fukasawa k. Acta Crystallogr D Biol Crystallogr. 2010 May;66(Pt 5):577-83. doi: 10.1107/S0907444910005639. Epub 2010 Apr 21. Acta Crystallogr D Biol Crystallogr. 2010. PMID: 20445233

9

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

Yoshinari T, Ohkubo M, Fukasawa K, Egashira S, Hara Y, Matsumoto M, Nakai K, Arakawa H, Morishima H, Nishimura S. Yoshinari T, et al. Among authors: fukasawa k. Cancer Res. 1999 Sep 1;59(17):4271-5. Cancer Res. 1999. PMID: 10485471

10

Sequence-selective DNA cleavage by a topoisomerase I poison, NB-506.

Fukasawa K, Komatani H, Hara Y, Suda H, Okura A, Nishimura S, Yoshinari T. Fukasawa K, et al. Int J Cancer. 1998 Jan 5;75(1):145-50. doi: 10.1002/(sici)1097-0215(19980105)75:1<145::aid-ijc22>3.0.co;2-e. Int J Cancer. 1998. PMID: 9426703 Free article.

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