Cottens S - Search Results

1

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. Brinkmann V, et al. Among authors: cottens s. J Biol Chem. 2002 Jun 14;277(24):21453-7. doi: 10.1074/jbc.C200176200. Epub 2002 Apr 19. J Biol Chem. 2002. PMID: 11967257 Free article.

2

FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects.

Brinkmann V, Wilt C, Kristofic C, Nikolova Z, Hof RP, Chen S, Albert R, Cottens S. Brinkmann V, et al. Among authors: cottens s. Transplant Proc. 2001 Nov-Dec;33(7-8):3078-80. doi: 10.1016/s0041-1345(01)02312-0. Transplant Proc. 2001. PMID: 11750323 No abstract available.

3

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U. Weitz-Schmidt G, et al. Among authors: cottens s. Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058. Nat Med. 2001. PMID: 11385505

4

Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.

Wagner J, von Matt P, Faller B, Cooke NG, Albert R, Sedrani R, Wiegand H, Jean C, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Wagner J, et al. Among authors: cottens s. J Med Chem. 2011 Sep 8;54(17):6028-39. doi: 10.1021/jm200469u. Epub 2011 Aug 8. J Med Chem. 2011. PMID: 21797275

5

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Wagner J, et al. Among authors: cottens s. J Med Chem. 2009 Oct 22;52(20):6193-6. doi: 10.1021/jm901108b. J Med Chem. 2009. PMID: 19827831

6

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G. Evenou JP, et al. Among authors: cottens s. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205. Epub 2009 Jun 2. J Pharmacol Exp Ther. 2009. PMID: 19491325

7

SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.

Schuler W, Sedrani R, Cottens S, Häberlin B, Schulz M, Schuurman HJ, Zenke G, Zerwes HG, Schreier MH. Schuler W, et al. Among authors: cottens s. Transplantation. 1997 Jul 15;64(1):36-42. doi: 10.1097/00007890-199707150-00008. Transplantation. 1997. PMID: 9233698

8

Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720.

Wijkstrom M, Kenyon NS, Kirchhof N, Kenyon NM, Mullon C, Lake P, Cottens S, Ricordi C, Hering BJ. Wijkstrom M, et al. Among authors: cottens s. Transplantation. 2004 Mar 27;77(6):827-35. doi: 10.1097/01.tp.0000116390.76425.20. Transplantation. 2004. PMID: 15077021

9

Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity.

Sedrani R, Jones LH, Jutzi-Eme AM, Schuler W, Cottens S. Sedrani R, et al. Among authors: cottens s. Bioorg Med Chem Lett. 1999 Feb 8;9(3):459-62. doi: 10.1016/s0960-894x(99)00007-4. Bioorg Med Chem Lett. 1999. PMID: 10091702

10

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.

Sellner H, Cottens S, Cumin F, Ehrhardt C, Kosaka T, Lorthiois E, Ostermann N, Webb RL, Rigel DF, Wagner T, Maibaum J. Sellner H, et al. Among authors: cottens s. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1787-1791. doi: 10.1016/j.bmcl.2015.02.040. Epub 2015 Feb 23. Bioorg Med Chem Lett. 2015. PMID: 25754490

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