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Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.
Denton CP, Zheng B, Evans LA, Shi-wen X, Ong VH, Fisher I, Lazaridis K, Abraham DJ, Black CM, de Crombrugghe B. Denton CP, et al. Among authors: de crombrugghe b. J Biol Chem. 2003 Jul 4;278(27):25109-19. doi: 10.1074/jbc.M300636200. Epub 2003 Apr 21. J Biol Chem. 2003. PMID: 12707256 Free article.
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.
Akiyama H, Kim JE, Nakashima K, Balmes G, Iwai N, Deng JM, Zhang Z, Martin JF, Behringer RR, Nakamura T, de Crombrugghe B. Akiyama H, et al. Among authors: de crombrugghe b. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70. doi: 10.1073/pnas.0504750102. Epub 2005 Oct 3. Proc Natl Acad Sci U S A. 2005. PMID: 16203988 Free PMC article.
An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes.
Lefebvre V, Zhou G, Mukhopadhyay K, Smith CN, Zhang Z, Eberspaecher H, Zhou X, Sinha S, Maity SN, de Crombrugghe B. Lefebvre V, et al. Among authors: de crombrugghe b. Mol Cell Biol. 1996 Aug;16(8):4512-23. doi: 10.1128/MCB.16.8.4512. Mol Cell Biol. 1996. PMID: 8754852 Free PMC article.
291 results