Maxwell PH - Search Results

1

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.

Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Mole DR, et al. Among authors: maxwell ph. Adv Enzyme Regul. 2002;42:333-47. doi: 10.1016/s0065-2571(01)00037-1. Adv Enzyme Regul. 2002. PMID: 12123724 No abstract available.

2

Oxygen sensors and angiogenesis.

Maxwell PH, Ratcliffe PJ. Maxwell PH, et al. Semin Cell Dev Biol. 2002 Feb;13(1):29-37. doi: 10.1006/scdb.2001.0287. Semin Cell Dev Biol. 2002. PMID: 11969369 Review.

3

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY. Hon WC, et al. Among authors: maxwell ph. Nature. 2002 Jun 27;417(6892):975-8. doi: 10.1038/nature00767. Epub 2002 Jun 5. Nature. 2002. PMID: 12050673

4

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.

Willam C, Nicholls LG, Ratcliffe PJ, Pugh CW, Maxwell PH. Willam C, et al. Among authors: maxwell ph. Adv Enzyme Regul. 2004;44:75-92. doi: 10.1016/j.advenzreg.2003.11.017. Adv Enzyme Regul. 2004. PMID: 15581484 Review. No abstract available.

5

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Raval RR, et al. Among authors: maxwell ph. Mol Cell Biol. 2005 Jul;25(13):5675-86. doi: 10.1128/MCB.25.13.5675-5686.2005. Mol Cell Biol. 2005. PMID: 15964822 Free PMC article.

6

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Cockman ME, et al. Among authors: maxwell ph. J Biol Chem. 2000 Aug 18;275(33):25733-41. doi: 10.1074/jbc.M002740200. J Biol Chem. 2000. PMID: 10823831 Free article.

7

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Jaakkola P, et al. Among authors: maxwell ph. Science. 2001 Apr 20;292(5516):468-72. doi: 10.1126/science.1059796. Epub 2001 Apr 5. Science. 2001. PMID: 11292861

8

Activation of the HIF pathway in cancer.

Maxwell PH, Pugh CW, Ratcliffe PJ. Maxwell PH, et al. Curr Opin Genet Dev. 2001 Jun;11(3):293-9. doi: 10.1016/s0959-437x(00)00193-3. Curr Opin Genet Dev. 2001. PMID: 11377966 Review.

9

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.

Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Masson N, et al. Among authors: maxwell ph. EMBO J. 2001 Sep 17;20(18):5197-206. doi: 10.1093/emboj/20.18.5197. EMBO J. 2001. PMID: 11566883 Free PMC article.

10

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: maxwell ph. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.

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