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Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.
Müller SG, Heckel A, Kley JT, Lehmann T, Lustenberger P, Oost T, Roth GJ, Rudolf K, Arndt K, Lenter M, Lotz RR, Maier GM, Markert M, Schindler M, Stenkamp D. Müller SG, et al. Among authors: schindler m. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3264-9. doi: 10.1016/j.bmcl.2015.05.077. Epub 2015 Jun 6. Bioorg Med Chem Lett. 2015. PMID: 26112443
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.
Roth GJ, Heckel A, Kley JT, Lehmann T, Müller SG, Oost T, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Schindler M, Thomas L, Stenkamp D. Roth GJ, et al. Among authors: schindler m. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3270-4. doi: 10.1016/j.bmcl.2015.05.074. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26077492
PYY3-36 as an anti-obesity drug target.
Boggiano MM, Chandler PC, Oswald KD, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Schindler M, Arndt K, Rudolf K, Mark M, Schoelch C, Joost HG, Klaus S, Thöne-Reineke C, Benoit SC, Seeley RJ, Beck-Sickinger AG, Koglin N, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Ortmann S, Castañeda TR, Tschöp M. Boggiano MM, et al. Among authors: schindler m. Obes Rev. 2005 Nov;6(4):307-22. doi: 10.1111/j.1467-789X.2005.00218.x. Obes Rev. 2005. PMID: 16246216 Review.
Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran TH, Beck-sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Schindler M, Arndt K, Rudolf K, Mark M, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman ML. Tschöp M, et al. Among authors: schindler m. Nature. 2004 Jul 8;430(6996):1 p following 165; discussion 2 p following 165. doi: 10.1038/nature02665. Nature. 2004. PMID: 15243972
625 results