Le Bourdonnec B - Search Results

1

Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.

Le Bourdonnec B, Cauvin C, Meulon E, Yous S, Goossens JF, Durant F, Houssin R, Hénichart JP. Le Bourdonnec B, et al. J Med Chem. 2002 Oct 10;45(21):4794-8. doi: 10.1021/jm010457z. J Med Chem. 2002. PMID: 12361407

2

Synthesis and pharmacological evaluation of new pyrazolidine-3, 5-diones as AT(1) angiotensin II receptor antagonists.

Le Bourdonnec B, Meulon E, Yous S, Goossens JF, Houssin R, Hénichart JP. Le Bourdonnec B, et al. J Med Chem. 2000 Jul 13;43(14):2685-97. doi: 10.1021/jm9904147. J Med Chem. 2000. PMID: 10893306

3

Pyrazolidine-3,5-dione angiotensin-II receptor antagonists.

Cauvin C, Le Bourdonnec B, Norberg B, Hénichart JP, Durant F. Cauvin C, et al. Among authors: le bourdonnec b. Acta Crystallogr C. 2001 Nov;57(Pt 11):1330-2. doi: 10.1107/s0108270101013506. Epub 2001 Nov 13. Acta Crystallogr C. 2001. PMID: 11706265

4

Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.

Le Bourdonnec B, Goodman AJ, Michaut M, Ye HF, Graczyk TM, Belanger S, Herbertz T, Yap GP, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. J Med Chem. 2006 Dec 14;49(25):7278-89. doi: 10.1021/jm060486f. J Med Chem. 2006. PMID: 17149858

5

Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.

Le Bourdonnec B, Goodman AJ, Graczyk TM, Belanger S, Seida PR, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. J Med Chem. 2006 Dec 14;49(25):7290-306. doi: 10.1021/jm0604878. J Med Chem. 2006. PMID: 17149859

To better understand structural requirements for a mu ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class to interact with the mu opioid receptor, we have described in the previous article (Le Bourdonnec, B. et al. J. Med. Chem. 2006, 25, 727 …

To better understand structural requirements for a mu ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class to interact with …

6

trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists.

Le Bourdonnec B, Belanger S, Cassel JA, Stabley GJ, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4459-62. doi: 10.1016/j.bmcl.2003.09.012. Bioorg Med Chem Lett. 2003. PMID: 14643346

7

Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists.

Le Bourdonnec B, Goodman AJ, Michaut M, Ye HF, Graczyk TM, Belanger S, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):864-8. doi: 10.1016/j.bmcl.2005.11.010. Epub 2005 Nov 18. Bioorg Med Chem Lett. 2006. PMID: 16298525

8

Discovery of a series of aminopiperidines as novel iNOS inhibitors.

Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE. Le Bourdonnec B, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. doi: 10.1016/j.bmcl.2007.10.073. Epub 2007 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 18024030

9

Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).

Le Bourdonnec B, Windh RT, Leister LK, Zhou QJ, Ajello CW, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE. Le Bourdonnec B, et al. J Med Chem. 2009 Sep 24;52(18):5685-702. doi: 10.1021/jm900773n. J Med Chem. 2009. PMID: 19694468

10

Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.

Le Bourdonnec B, Barker WM, Belanger S, Wiant DD, Conway-James NC, Cassel JA, O'Neill TJ, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE. Le Bourdonnec B, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12. doi: 10.1016/j.bmcl.2008.01.106. Epub 2008 Feb 2. Bioorg Med Chem Lett. 2008. PMID: 18313920

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