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Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
Mol Cancer Ther. 2002 Apr;1(6):377-84.
Mol Cancer Ther. 2002.
PMID: 12477050
Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Boyer CR, Karjian PL, Wahl GM, Pegram M, Neuteboom ST.
Boyer CR, et al. Among authors: karjian pl.
Anticancer Drugs. 2002 Jan;13(1):29-36. doi: 10.1097/00001813-200201000-00003.
Anticancer Drugs. 2002.
PMID: 11914638
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NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint.
Dellinger RW, Karjian PL, Neuteboom ST.
Dellinger RW, et al. Among authors: karjian pl.
Anticancer Drugs. 2003 Jul;14(6):449-55. doi: 10.1097/00001813-200307000-00011.
Anticancer Drugs. 2003.
PMID: 12853888
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Dimeric ansamycins--a new class of antitumor Hsp90 modulators with prolonged inhibitory activity.
Zhang H, Yang YC, Zhang L, Fan J, Chung D, Choi D, Grecko R, Timony G, Karjian P, Boehm M, Burrows F.
Zhang H, et al.
Int J Cancer. 2007 Feb 15;120(4):918-26. doi: 10.1002/ijc.22392.
Int J Cancer. 2007.
PMID: 17131314
Free article.
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Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Kasibhatla SR, Hong K, Biamonte MA, Busch DJ, Karjian PL, Sensintaffar JL, Kamal A, Lough RE, Brekken J, Lundgren K, Grecko R, Timony GA, Ran Y, Mansfield R, Fritz LC, Ulm E, Burrows FJ, Boehm MF.
Kasibhatla SR, et al. Among authors: karjian pl.
J Med Chem. 2007 Jun 14;50(12):2767-78. doi: 10.1021/jm050752+. Epub 2007 May 8.
J Med Chem. 2007.
PMID: 17488003
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Orally active purine-based inhibitors of the heat shock protein 90.
Biamonte MA, Shi J, Hong K, Hurst DC, Zhang L, Fan J, Busch DJ, Karjian PL, Maldonado AA, Sensintaffar JL, Yang YC, Kamal A, Lough RE, Lundgren K, Burrows FJ, Timony GA, Boehm MF, Kasibhatla SR.
Biamonte MA, et al. Among authors: karjian pl.
J Med Chem. 2006 Jan 26;49(2):817-28. doi: 10.1021/jm0503087.
J Med Chem. 2006.
PMID: 16420067
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