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Development of interleukin-1 receptor antagonist mutants with enhanced antagonistic activity in vitro and improved therapeutic efficacy in collagen-induced arthritis.
Dahlén E, Barchan K, Herrlander D, Höjman P, Karlsson M, Ljung L, Andersson M, Bäckman E, Hager AC, Walse B, Joosten L, van den Berg W. Dahlén E, et al. Among authors: hager ac. J Immunotoxicol. 2008 Apr;5(2):189-99. doi: 10.1080/15476910802131477. J Immunotoxicol. 2008. PMID: 18569390
Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis.
Knecht W, Willemse J, Stenhamre H, Andersson M, Berntsson P, Furebring C, Harrysson A, Hager AC, Wissing BM, Hendriks D, Cronet P. Knecht W, et al. Among authors: hager ac. FEBS J. 2006 Feb;273(4):778-92. doi: 10.1111/j.1742-4658.2006.05110.x. FEBS J. 2006. PMID: 16441664 Free article.