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Extra-embryonic function of Rb is essential for embryonic development and viability.
Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML, Leone G. Wu L, et al. Among authors: saavedra hi. Nature. 2003 Feb 27;421(6926):942-7. doi: 10.1038/nature01417. Nature. 2003. PMID: 12607001
The E2F1-3 transcription factors are essential for cellular proliferation.
Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. Wu L, et al. Among authors: saavedra hi. Nature. 2001 Nov 22;414(6862):457-62. doi: 10.1038/35106593. Nature. 2001. PMID: 11719808
Aberrant regulation of survivin by the RB/E2F family of proteins.
Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA. Jiang Y, et al. Among authors: saavedra hi. J Biol Chem. 2004 Sep 24;279(39):40511-20. doi: 10.1074/jbc.M404496200. Epub 2004 Jul 22. J Biol Chem. 2004. PMID: 15271987 Free article.
Inactivation of E2F3 results in centrosome amplification.
Saavedra HI, Maiti B, Timmers C, Altura R, Tokuyama Y, Fukasawa K, Leone G. Saavedra HI, et al. Cancer Cell. 2003 Apr;3(4):333-46. doi: 10.1016/s1535-6108(03)00083-7. Cancer Cell. 2003. PMID: 12726860 Free PMC article.
Myc requires distinct E2F activities to induce S phase and apoptosis.
Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Leone G, et al. Among authors: saavedra hi. Mol Cell. 2001 Jul;8(1):105-13. doi: 10.1016/s1097-2765(01)00275-1. Mol Cell. 2001. PMID: 11511364 Free article.
41 results