Polar residues in helix VIII of subunit I of cytochrome c oxidase influence the activity and the structure of the active site.
Hosler JP, Shapleigh JP, Mitchell DM, Kim Y, Pressler MA, Georgiou C, Babcock GT, Alben JO, Ferguson-Miller S, Gennis RB.
Hosler JP, et al.
Biochemistry. 1996 Aug 20;35(33):10776-83. doi: 10.1021/bi9606511.
Biochemistry. 1996.
PMID: 8718868
Analysis of site-directed mutants identified the ligands of heme a, heme a3, and CuB [Hosler et al. (1993) J. Bioenerg. Biomembr. 25, 121-133], which have been confirmed by high-resolution structures of homologous oxidases [Iwata et al. (1995) Nature 376, 660; Tsuki …
Analysis of site-directed mutants identified the ligands of heme a, heme a3, and CuB [Hosler et al. (1993) J. Bioenerg. Biomem …