Coombes RC - Search Results

1

Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.

Vigushin DM, Brooke G, Willows D, Coombes RC, Moody CJ. Vigushin DM, et al. Among authors: coombes rc. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3661-3. doi: 10.1016/j.bmcl.2003.08.022. Bioorg Med Chem Lett. 2003. PMID: 14552752

2

Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.

Marson CM, Rioja AS, Brooke G, Coombes RC, Vigushin DM. Marson CM, et al. Among authors: coombes rc. Bioorg Med Chem Lett. 2002 Jan 21;12(2):255-9. doi: 10.1016/s0960-894x(01)00718-1. Bioorg Med Chem Lett. 2002. PMID: 11755366

3

Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

Vigushin DM, Mirsaidi N, Brooke G, Sun C, Pace P, Inman L, Moody CJ, Coombes RC. Vigushin DM, et al. Among authors: coombes rc. Med Oncol. 2004;21(1):21-30. doi: 10.1385/MO:21:1:21. Med Oncol. 2004. PMID: 15034210

4

Histone deacetylase inhibitors in cancer treatment.

Vigushin DM, Coombes RC. Vigushin DM, et al. Among authors: coombes rc. Anticancer Drugs. 2002 Jan;13(1):1-13. doi: 10.1097/00001813-200201000-00001. Anticancer Drugs. 2002. PMID: 11914636 Review.

5

Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.

Marson CM, Serradji N, Rioja AS, Gastaud SP, Alao JP, Coombes RC, Vigushin DM. Marson CM, et al. Among authors: coombes rc. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. doi: 10.1016/j.bmcl.2004.03.012. Bioorg Med Chem Lett. 2004. PMID: 15109636

6

Targeted histone deacetylase inhibition for cancer prevention and therapy.

Palmieri C, Coombes RC, Vigushin DM. Palmieri C, et al. Among authors: coombes rc. Prog Drug Res. 2005;63:147-81. doi: 10.1007/3-7643-7414-4_7. Prog Drug Res. 2005. PMID: 16265880 Review. No abstract available.

7

Targeted histone deacetylase inhibition for cancer therapy.

Vigushin DM, Coombes RC. Vigushin DM, et al. Among authors: coombes rc. Curr Cancer Drug Targets. 2004 Mar;4(2):205-18. doi: 10.2174/1568009043481560. Curr Cancer Drug Targets. 2004. PMID: 15032670 Review.

8

ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.

Varshochi R, Halim F, Sunters A, Alao JP, Madureira PA, Hart SM, Ali S, Vigushin DM, Coombes RC, Lam EW. Varshochi R, et al. Among authors: coombes rc. J Biol Chem. 2005 Feb 4;280(5):3185-96. doi: 10.1074/jbc.M408063200. Epub 2004 Nov 19. J Biol Chem. 2005. PMID: 15557281 Free article.

9

Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.

Alao JP, Stavropoulou AV, Lam EW, Coombes RC, Vigushin DM. Alao JP, et al. Among authors: coombes rc. Mol Cancer. 2006 Feb 20;5:8. doi: 10.1186/1476-4598-5-8. Mol Cancer. 2006. PMID: 16504004 Free PMC article.

10

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.

Alao JP, Lam EW, Ali S, Buluwela L, Bordogna W, Lockey P, Varshochi R, Stavropoulou AV, Coombes RC, Vigushin DM. Alao JP, et al. Among authors: coombes rc. Clin Cancer Res. 2004 Dec 1;10(23):8094-104. doi: 10.1158/1078-0432.CCR-04-1023. Clin Cancer Res. 2004. PMID: 15585645

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