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Page 1
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Zambrowicz BP, et al. Among authors: van sligtenhorst i. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14. doi: 10.1073/pnas.2336103100. Epub 2003 Nov 10. Proc Natl Acad Sci U S A. 2003. PMID: 14610273 Free PMC article.
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.
Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT, Schneider M, Van Sligtenhorst I, Suwanichkul A, Vogel P, Wilganowski N, Wingert J, Zambrowicz BP, Landes G, Powell DR. Desai U, et al. Among authors: van sligtenhorst i. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71. doi: 10.1073/pnas.0705041104. Epub 2007 Jul 3. Proc Natl Acad Sci U S A. 2007. PMID: 17609370 Free PMC article.
Cardiomyopathy in α-kinase 3 (ALPK3)-deficient mice.
Van Sligtenhorst I, Ding ZM, Shi ZZ, Read RW, Hansen G, Vogel P. Van Sligtenhorst I, et al. Vet Pathol. 2012 Jan;49(1):131-41. doi: 10.1177/0300985811402841. Epub 2011 Mar 25. Vet Pathol. 2012. PMID: 21441111
Profound obesity secondary to hyperphagia in mice lacking kinase suppressor of ras 2.
Revelli JP, Smith D, Allen J, Jeter-Jones S, Shadoan MK, Desai U, Schneider M, van Sligtenhorst I, Kirkpatrick L, Platt KA, Suwanichkul A, Savelieva K, Gerhardt B, Mitchell J, Syrewicz J, Zambrowicz B, Hamman BD, Vogel P, Powell DR. Revelli JP, et al. Among authors: van sligtenhorst i. Obesity (Silver Spring). 2011 May;19(5):1010-8. doi: 10.1038/oby.2010.282. Epub 2010 Dec 2. Obesity (Silver Spring). 2011. PMID: 21127480 Free article.
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.
Powell DR, Gay JP, Smith M, Wilganowski N, Harris A, Holland A, Reyes M, Kirkham L, Kirkpatrick LL, Zambrowicz B, Hansen G, Platt KA, van Sligtenhorst I, Ding ZM, Desai U. Powell DR, et al. Among authors: van sligtenhorst i. Diabetes Metab Syndr Obes. 2016 Jun 22;9:185-99. doi: 10.2147/DMSO.S106653. eCollection 2016. Diabetes Metab Syndr Obes. 2016. PMID: 27382320 Free PMC article.
Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3.
Bok D, Galbraith G, Lopez I, Woodruff M, Nusinowitz S, BeltrandelRio H, Huang W, Zhao S, Geske R, Montgomery C, Van Sligtenhorst I, Friddle C, Platt K, Sparks MJ, Pushkin A, Abuladze N, Ishiyama A, Dukkipati R, Liu W, Kurtz I. Bok D, et al. Among authors: van sligtenhorst i. Nat Genet. 2003 Jul;34(3):313-9. doi: 10.1038/ng1176. Nat Genet. 2003. PMID: 12808454