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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Zambrowicz BP, et al. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14. doi: 10.1073/pnas.2336103100. Epub 2003 Nov 10. Proc Natl Acad Sci U S A. 2003. PMID: 14610273 Free PMC article.
Gene trap mutagenesis.
Abuin A, Hansen GM, Zambrowicz B. Abuin A, et al. Handb Exp Pharmacol. 2007;(178):129-47. doi: 10.1007/978-3-540-35109-2_6. Handb Exp Pharmacol. 2007. PMID: 17203654 Review.
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.
Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT, Schneider M, Van Sligtenhorst I, Suwanichkul A, Vogel P, Wilganowski N, Wingert J, Zambrowicz BP, Landes G, Powell DR. Desai U, et al. Among authors: zambrowicz bp. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71. doi: 10.1073/pnas.0705041104. Epub 2007 Jul 3. Proc Natl Acad Sci U S A. 2007. PMID: 17609370 Free PMC article.
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A. Hansen GM, et al. Among authors: zambrowicz bp. Genome Res. 2008 Oct;18(10):1670-9. doi: 10.1101/gr.078352.108. Epub 2008 Sep 17. Genome Res. 2008. PMID: 18799693 Free PMC article.
High-throughput mouse knockouts provide a functional analysis of the genome.
Friddle CJ, Abuin A, Ramirez-Solis R, Richter LJ, Buxton EC, Edwards J, Finch RA, Gupta A, Hansen G, Holt KH, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Newhouse M, Perry T, Platt KA, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Tran D, Wann ER, Walke W, Wallace JD, Xu N, Zhu Q, Person C, Sands AT, Zambrowicz BP. Friddle CJ, et al. Among authors: zambrowicz bp. Cold Spring Harb Symp Quant Biol. 2003;68:311-5. doi: 10.1101/sqb.2003.68.311. Cold Spring Harb Symp Quant Biol. 2003. PMID: 15338631 No abstract available.
77 results