Joseph-McCarthy D - Search Results

1

Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.

Gilbert AM, Kirisits M, Toy P, Nunn DS, Failli A, Dushin EG, Novikova E, Petersen PJ, Joseph-McCarthy D, McFadyen I, Fritz CC. Gilbert AM, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):37-41. doi: 10.1016/j.bmcl.2003.10.032. Bioorg Med Chem Lett. 2004. PMID: 14684293

2

Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.

Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Joseph-McCarthy D, et al. J Med Chem. 2005 Dec 15;48(25):7960-9. doi: 10.1021/jm050523n. J Med Chem. 2005. PMID: 16335920

3

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.

Cole DC, Asselin M, Brennan A, Czerwinski R, Ellingboe JW, Fitz L, Greco R, Huang X, Joseph-McCarthy D, Kelly MF, Kirisits M, Lee J, Li Y, Morgan P, Stock JR, Tsao DH, Wissner A, Yang X, Chaudhary D. Cole DC, et al. J Med Chem. 2008 Oct 9;51(19):5958-63. doi: 10.1021/jm800214a. Epub 2008 Sep 11. J Med Chem. 2008. PMID: 18783200

4

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.

Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J. Moretto AF, et al. Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. doi: 10.1016/j.bmc.2005.11.005. Epub 2005 Nov 21. Bioorg Med Chem. 2006. PMID: 16303309

5

Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.

Wan ZK, Lee J, Xu W, Erbe DV, Joseph-McCarthy D, Follows BC, Zhang YL. Wan ZK, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4941-5. doi: 10.1016/j.bmcl.2006.06.051. Epub 2006 Jun 27. Bioorg Med Chem Lett. 2006. PMID: 16806920

6

Probing acid replacements of thiophene PTP1B inhibitors.

Wan ZK, Follows B, Kirincich S, Wilson D, Binnun E, Xu W, Joseph-McCarthy D, Wu J, Smith M, Zhang YL, Tam M, Erbe D, Tam S, Saiah E, Lee J. Wan ZK, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2913-20. doi: 10.1016/j.bmcl.2007.02.043. Epub 2007 Feb 20. Bioorg Med Chem Lett. 2007. PMID: 17336064

7

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.

Gopalsamy A, Yang H, Ellingboe JW, McKew JC, Tam S, Joseph-McCarthy D, Zhang W, Shen M, Clark JD. Gopalsamy A, et al. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2978-81. doi: 10.1016/j.bmcl.2006.02.067. Epub 2006 Mar 20. Bioorg Med Chem Lett. 2006. PMID: 16545564

8

Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.

Lombart HG, Feyfant E, Joseph-McCarthy D, Huang A, Lovering F, Sun L, Zhu Y, Zeng C, Zhang Y, Levin J. Lombart HG, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4333-7. doi: 10.1016/j.bmcl.2007.05.022. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17531482

9

Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.

Huang A, Joseph-McCarthy D, Lovering F, Sun L, Wang W, Xu W, Zhu Y, Cui J, Zhang Y, Levin JI. Huang A, et al. Bioorg Med Chem. 2007 Sep 15;15(18):6170-81. doi: 10.1016/j.bmc.2007.06.031. Epub 2007 Jun 20. Bioorg Med Chem. 2007. PMID: 17606376

10

Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

McKew JC, Lovering F, Clark JD, Bemis J, Xiang Y, Shen M, Zhang W, Alvarez JC, Joseph-McCarthy D. McKew JC, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4501-4. doi: 10.1016/j.bmcl.2003.08.070. Bioorg Med Chem Lett. 2003. PMID: 14643356

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