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Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.
Richardson TI, Ornstein PL, Briner K, Fisher MJ, Backer RT, Biggers CK, Clay MP, Emmerson PJ, Hertel LW, Hsiung HM, Husain S, Kahl SD, Lee JA, Lindstrom TD, Martinelli MJ, Mayer JP, Mullaney JT, O'Brien TP, Pawlak JM, Revell KD, Shah J, Zgombick JM, Herr RJ, Melekhov A, Sampson PB, King CH. Richardson TI, et al. Among authors: mullaney jt. J Med Chem. 2004 Jan 29;47(3):744-55. doi: 10.1021/jm0304109. J Med Chem. 2004. PMID: 14736255
Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives.
Fisher MJ, Backer RT, Collado I, de Frutos O, Husain S, Hsiung HM, Kuklish SL, Mateo AI, Mullaney JT, Ornstein PL, Paredes CG, O'Brian TP, Richardson TI, Shah J, Zgombick JM, Briner K. Fisher MJ, et al. Among authors: mullaney jt. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4973-8. doi: 10.1016/j.bmcl.2005.08.018. Bioorg Med Chem Lett. 2005. PMID: 16169215
Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor.
Shi Q, Ornstein PL, Briner K, Richardson TI, Arnold MB, Backer RT, Buckmaster JL, Canada EJ, Doecke CW, Hertel LW, Honigschmidt N, Hsiung HM, Husain S, Kuklish SL, Martinelli MJ, Mullaney JT, O'Brien TP, Reinhard MR, Rothhaar R, Shah J, Wu Z, Xie C, Zgombick JM, Fisher MJ. Shi Q, et al. Among authors: mullaney jt. Bioorg Med Chem Lett. 2006 May 1;16(9):2341-6. doi: 10.1016/j.bmcl.2005.10.103. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16297618
Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa.
Fisher MJ, Arfstan AE, Giese U, Gunn BP, Harms CS, Khau V, Kinnick MD, Lindstrom TD, Martinelli MJ, Mest HJ, Mohr M, Morin JM Jr, Mullaney JT, Nunes A, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Sommer B, Stenzel W, Towner RD, Um SL, et al. Fisher MJ, et al. Among authors: mullaney jt. J Med Chem. 1999 Nov 18;42(23):4875-89. doi: 10.1021/jm990365y. J Med Chem. 1999. PMID: 10579850
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.
Fisher MJ, Giese U, Harms CS, Kinnick MD, Lindstrom TD, McCowan JR, Mest HJ, Morin JM Jr, Mullaney JT, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Stenzel W, Towner RD, Um SL, Utterback BG, Wyss VL, Jakubowski JA. Fisher MJ, et al. Among authors: mullaney jt. Bioorg Med Chem Lett. 2000 Feb 21;10(4):385-9. doi: 10.1016/s0960-894x(00)00008-1. Bioorg Med Chem Lett. 2000. PMID: 10714506
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