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Page 1
Novel non-peptidic neuropeptide Y Y2 receptor antagonists.
Jablonowski JA, Chai W, Li X, Rudolph DA, Murray WV, Youngman MA, Dax SL, Nepomuceno D, Bonaventure P, Lovenberg TW, Carruthers NI. Jablonowski JA, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1239-42. doi: 10.1016/j.bmcl.2003.12.057. Bioorg Med Chem Lett. 2004. PMID: 14980673
Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor.
Bonaventure P, Nepomuceno D, Mazur C, Lord B, Rudolph DA, Jablonowski JA, Carruthers NI, Lovenberg TW. Bonaventure P, et al. Among authors: nepomuceno d. J Pharmacol Exp Ther. 2004 Mar;308(3):1130-7. doi: 10.1124/jpet.103.060459. Epub 2003 Nov 14. J Pharmacol Exp Ther. 2004. PMID: 14617685
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Ly KS, Letavic MA, Keith JM, Miller JM, Stocking EM, Barbier AJ, Bonaventure P, Lord B, Jiang X, Boggs JD, Dvorak L, Miller KL, Nepomuceno D, Wilson SJ, Carruthers NI. Ly KS, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2008 Jan 1;18(1):39-43. doi: 10.1016/j.bmcl.2007.11.016. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18060777
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.
Shireman BT, Dvorak CA, Rudolph DA, Bonaventure P, Nepomuceno D, Dvorak L, Miller KL, Lovenberg TW, Carruthers NI. Shireman BT, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2103-8. doi: 10.1016/j.bmcl.2008.01.090. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18282705
2-Aryloxymethylmorpholine histamine H(3) antagonists.
Letavic MA, Keith JM, Ly KS, Bonaventure P, Feinstein MA, Lord B, Miller KL, Motley ST, Nepomuceno D, Sutton SW, Carruthers NI. Letavic MA, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5796-9. doi: 10.1016/j.bmcl.2008.09.077. Epub 2008 Sep 24. Bioorg Med Chem Lett. 2008. PMID: 18922693
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Stocking EM, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Fraser I, Jiang X, Leung P, Lord B, Ly KS, Morton KL, Nepomuceno D, Shah CR, Shelton J, Soyode-Johnson A, Letavic MA. Stocking EM, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2010 May 1;20(9):2755-60. doi: 10.1016/j.bmcl.2010.03.071. Epub 2010 Mar 20. Bioorg Med Chem Lett. 2010. PMID: 20382018
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Letavic MA, Aluisio L, Atack JR, Bonaventure P, Carruthers NI, Dugovic C, Everson A, Feinstein MA, Fraser IC, Hoey K, Jiang X, Keith JM, Koudriakova T, Leung P, Lord B, Lovenberg TW, Ly KS, Morton KL, Motley ST, Nepomuceno D, Rizzolio M, Rynberg R, Sepassi K, Shelton J. Letavic MA, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4. doi: 10.1016/j.bmcl.2010.05.041. Epub 2010 May 16. Bioorg Med Chem Lett. 2010. PMID: 20561786
Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.
Rudolph DA, Dvorak CA, Dvorak L, Nepomuceno D, Bonaventure P, Lovenberg TW, Carruthers NI. Rudolph DA, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2011 Jan 1;21(1):42-4. doi: 10.1016/j.bmcl.2010.11.078. Epub 2010 Nov 24. Bioorg Med Chem Lett. 2011. PMID: 21159507
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.
Swanson DM, Wong VD, Jablonowski JA, Shah C, Rudolph DA, Dvorak CA, Seierstad M, Dvorak LK, Morton K, Nepomuceno D, Atack JR, Bonaventure P, Lovenberg TW, Carruthers NI. Swanson DM, et al. Among authors: nepomuceno d. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5552-6. doi: 10.1016/j.bmcl.2011.06.136. Epub 2011 Jul 18. Bioorg Med Chem Lett. 2011. PMID: 21802951
57 results