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A synthetic superoxide dismutase/catalase mimetic (EUK-134) inhibits membrane-damage-induced activation of mitogen-activated protein kinase pathways and reduces p53 accumulation in ultraviolet B-exposed primary human keratinocytes.
J Invest Dermatol. 2004 Feb;122(2):484-91. doi: 10.1046/j.0022-202X.2004.22215.x.
J Invest Dermatol. 2004.
PMID: 15009734
Free article.
AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway.
Decraene D, Van Laethem A, Agostinis P, De Peuter L, Degreef H, Bouillon R, Garmyn M.
Decraene D, et al.
J Invest Dermatol. 2004 Jul;123(1):207-12. doi: 10.1111/j.0022-202X.2004.22702.x.
J Invest Dermatol. 2004.
PMID: 15191562
Free article.
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A low UVB dose, with the potential to trigger a protective p53-dependent gene program, increases the resilience of keratinocytes against future UVB insults.
Decraene D, Smaers K, Maes D, Matsui M, Declercq L, Garmyn M.
Decraene D, et al.
J Invest Dermatol. 2005 Nov;125(5):1026-31. doi: 10.1111/j.0022-202X.2005.23909.x.
J Invest Dermatol. 2005.
PMID: 16297205
Free article.
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AKT delays the early-activated apoptotic pathway in UVB-irradiated keratinocytes via BAD translocation.
Claerhout S, Decraene D, Van Laethem A, Van Kelst S, Agostinis P, Garmyn M.
Claerhout S, et al. Among authors: decraene d.
J Invest Dermatol. 2007 Feb;127(2):429-38. doi: 10.1038/sj.jid.5700533. Epub 2006 Aug 24.
J Invest Dermatol. 2007.
PMID: 16932738
Free article.
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Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes.
Decraene D, Agostinis P, Bouillon R, Degreef H, Garmyn M.
Decraene D, et al.
J Biol Chem. 2002 Sep 6;277(36):32587-95. doi: 10.1074/jbc.M111106200. Epub 2002 Jun 17.
J Biol Chem. 2002.
PMID: 12070137
Free article.
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Acute response of human skin to solar radiation: regulation and function of the p53 protein.
Decraene D, Agostinis P, Pupe A, de Haes P, Garmyn M.
Decraene D, et al.
J Photochem Photobiol B. 2001 Oct;63(1-3):78-83. doi: 10.1016/s1011-1344(01)00204-4.
J Photochem Photobiol B. 2001.
PMID: 11684454
Review.
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Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, Diemert D, Spector SA, Rouphael N, Creech CB, McGettigan J, Khetan S, Segall N, Solis J, Brosz A, Fierro C, Schwartz H, Neuzil K, Corey L, Gilbert P, Janes H, Follmann D, Marovich M, Mascola J, Polakowski L, Ledgerwood J, Graham BS, Bennett H, Pajon R, Knightly C, Leav B, Deng W, Zhou H, Han S, Ivarsson M, Miller J, Zaks T; COVE Study Group.
Baden LR, et al.
N Engl J Med. 2021 Feb 4;384(5):403-416. doi: 10.1056/NEJMoa2035389. Epub 2020 Dec 30.
N Engl J Med. 2021.
PMID: 33378609
Free PMC article.
Clinical Trial.
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