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Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Kym PR, Kort ME, Coghlan MJ, Moore JL, Tang R, Ratajczyk JD, Larson DP, Elmore SW, Pratt JK, Stashko MA, Falls HD, Lin CW, Nakane M, Miller L, Tyree CM, Miner JN, Jacobson PB, Wilcox DM, Nguyen P, Lane BC. Kym PR, et al. Among authors: lane bc. J Med Chem. 2003 Mar 13;46(6):1016-30. doi: 10.1021/jm020335m. J Med Chem. 2003. PMID: 12620078
trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and its four stereoisomers.
Lin CW, Nakane M, Stashko M, Falls D, Kuk J, Miller L, Huang R, Tyree C, Miner JN, Rosen J, Kym PR, Coghlan MJ, Carter G, Lane BC. Lin CW, et al. Mol Pharmacol. 2002 Aug;62(2):297-303. doi: 10.1124/mol.62.2.297. Mol Pharmacol. 2002. PMID: 12130681
Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Elmore SW, Coghlan MJ, Anderson DD, Pratt JK, Green BE, Wang AX, Stashko MA, Lin CW, Tyree CM, Miner JN, Jacobson PB, Wilcox DM, Lane BC. Elmore SW, et al. Among authors: lane bc. J Med Chem. 2001 Dec 6;44(25):4481-91. doi: 10.1021/jm010367u. J Med Chem. 2001. PMID: 11728194
A nonsteroidal glucocorticoid receptor antagonist.
Miner JN, Tyree C, Hu J, Berger E, Marschke K, Nakane M, Coghlan MJ, Clemm D, Lane B, Rosen J. Miner JN, et al. Among authors: lane b. Mol Endocrinol. 2003 Jan;17(1):117-27. doi: 10.1210/me.2002-0010. Mol Endocrinol. 2003. PMID: 12511611
A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.
Coghlan MJ, Jacobson PB, Lane B, Nakane M, Lin CW, Elmore SW, Kym PR, Luly JR, Carter GW, Turner R, Tyree CM, Hu J, Elgort M, Rosen J, Miner JN. Coghlan MJ, et al. Among authors: lane b. Mol Endocrinol. 2003 May;17(5):860-9. doi: 10.1210/me.2002-0355. Epub 2003 Feb 13. Mol Endocrinol. 2003. PMID: 12586843
Synthesis and immunosuppressant activity of pyrazole carboxamides.
Wang AX, Xie Q, Lane B, Mollison KW, Hsieh GC, Marsh K, Sheets MP, Luly JR, Coghlan MJ. Wang AX, et al. Among authors: lane b. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2787-92. doi: 10.1016/s0960-894x(98)00501-0. Bioorg Med Chem Lett. 1998. PMID: 9873623
Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
Link JT, Sorensen B, Patel J, Grynfarb M, Goos-Nilsson A, Wang J, Fung S, Wilcox D, Zinker B, Nguyen P, Hickman B, Schmidt JM, Swanson S, Tian Z, Reisch TJ, Rotert G, Du J, Lane B, von Geldern TW, Jacobson PB. Link JT, et al. Among authors: lane b. J Med Chem. 2005 Aug 11;48(16):5295-304. doi: 10.1021/jm050205o. J Med Chem. 2005. PMID: 16078847
Rapamycin analogs with reduced systemic exposure.
Wagner R, Mollison KW, Liu L, Henry CL, Rosenberg TA, Bamaung N, Tu N, Wiedeman PE, Or Y, Luly JR, Lane BC, Trevillyan J, Chen YW, Fey T, Hsieh G, Marsh K, Nuss M, Jacobson PB, Wilcox D, Carlson RP, Carter GW, Djuric SW. Wagner R, et al. Among authors: lane bc. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5340-3. doi: 10.1016/j.bmcl.2005.06.106. Epub 2005 Sep 26. Bioorg Med Chem Lett. 2005. PMID: 16185865
1,237 results