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Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
Feng JY, Murakami E, Zorca SM, Johnson AA, Johnson KA, Schinazi RF, Furman PA, Anderson KS. Feng JY, et al. Among authors: furman pa. Antimicrob Agents Chemother. 2004 Apr;48(4):1300-6. doi: 10.1128/AAC.48.4.1300-1306.2004. Antimicrob Agents Chemother. 2004. PMID: 15047533 Free PMC article.
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
Furman PA, Jeffrey J, Kiefer LL, Feng JY, Anderson KS, Borroto-Esoda K, Hill E, Copeland WC, Chu CK, Sommadossi JP, Liberman I, Schinazi RF, Painter GR. Furman PA, et al. Antimicrob Agents Chemother. 2001 Jan;45(1):158-65. doi: 10.1128/AAC.45.1.158-165.2001. Antimicrob Agents Chemother. 2001. PMID: 11120959 Free PMC article.
In vitro combination of amdoxovir and the inosine monophosphate dehydrogenase inhibitors mycophenolic acid and ribavirin demonstrates potent activity against wild-type and drug-resistant variants of human immunodeficiency virus type 1.
Borroto-Esoda K, Myrick F, Feng J, Jeffrey J, Furman P. Borroto-Esoda K, et al. Antimicrob Agents Chemother. 2004 Nov;48(11):4387-94. doi: 10.1128/AAC.48.11.4387-4394.2004. Antimicrob Agents Chemother. 2004. PMID: 15504868 Free PMC article.
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
Schinazi RF, McMillan A, Cannon D, Mathis R, Lloyd RM, Peck A, Sommadossi JP, St Clair M, Wilson J, Furman PA, et al. Schinazi RF, et al. Among authors: furman pa. Antimicrob Agents Chemother. 1992 Nov;36(11):2423-31. doi: 10.1128/AAC.36.11.2423. Antimicrob Agents Chemother. 1992. PMID: 1283296 Free PMC article.
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Murakami E, Bao H, Ramesh M, McBrayer TR, Whitaker T, Micolochick Steuer HM, Schinazi RF, Stuyver LJ, Obikhod A, Otto MJ, Furman PA. Murakami E, et al. Among authors: furman pa. Antimicrob Agents Chemother. 2007 Feb;51(2):503-9. doi: 10.1128/AAC.00400-06. Epub 2006 Nov 13. Antimicrob Agents Chemother. 2007. PMID: 17101674 Free PMC article.
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Murakami E, Niu C, Bao H, Micolochick Steuer HM, Whitaker T, Nachman T, Sofia MA, Wang P, Otto MJ, Furman PA. Murakami E, et al. Among authors: furman pa. Antimicrob Agents Chemother. 2008 Feb;52(2):458-64. doi: 10.1128/AAC.01184-07. Epub 2007 Nov 12. Antimicrob Agents Chemother. 2008. PMID: 17999967 Free PMC article.
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