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Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action.
Vigliotta G, Miele C, Santopietro S, Portella G, Perfetti A, Maitan MA, Cassese A, Oriente F, Trencia A, Fiory F, Romano C, Tiveron C, Tatangelo L, Troncone G, Formisano P, Beguinot F. Vigliotta G, et al. Among authors: santopietro s. Mol Cell Biol. 2004 Jun;24(11):5005-15. doi: 10.1128/MCB.24.11.5005-5015.2004. Mol Cell Biol. 2004. PMID: 15143191 Free PMC article.
Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.
Condorelli G, Vigliotta G, Trencia A, Maitan MA, Caruso M, Miele C, Oriente F, Santopietro S, Formisano P, Beguinot F. Condorelli G, et al. Among authors: santopietro s. Diabetes. 2001 Jun;50(6):1244-52. doi: 10.2337/diabetes.50.6.1244. Diabetes. 2001. Retraction in: Diabetes. 2019 Feb;68(2):464-465. doi: 10.2337/db19-rt02b. PMID: 11375323 Retracted.
Expression of Concern. Protein Kinase C (PKC)-α Activation Inhibits PKC-ζ and Mediates the Action of PED/PEA-15 on Glucose Transport in the L6 Skeletal Muscle Cells. Diabetes 2001;50:1244-1252. DOI: https://doi.org/10.2337/diabetes.50.6.1244. PMID: 11375323.
Condorelli G, Vigliotta G, Trencia A, Maitan MA, Caruso M, Miele C, Oriente F, Santopietro S, Formisano P, Beguinot F. Condorelli G, et al. Among authors: santopietro s. Diabetes. 2017 Nov 6;67(2):345-6. doi: 10.2337/db17-ec2017b. Online ahead of print. Diabetes. 2017. PMID: 29109245 Free PMC article. No abstract available.
Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes.
Novosyadlyy R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo AA, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, LeRoith D. Novosyadlyy R, et al. Among authors: santopietro s. Cancer Res. 2010 Jan 15;70(2):741-51. doi: 10.1158/0008-5472.CAN-09-2141. Epub 2010 Jan 12. Cancer Res. 2010. PMID: 20068149 Free PMC article.
25 results