Degen JL - Search Results

1

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

Flick MJ, Du X, Witte DP, Jirousková M, Soloviev DA, Busuttil SJ, Plow EF, Degen JL. Flick MJ, et al. Among authors: degen jl. J Clin Invest. 2004 Jun;113(11):1596-606. doi: 10.1172/JCI20741. J Clin Invest. 2004. PMID: 15173886 Free PMC article.

2

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirousková M, Degen JL. Palumbo JS, et al. Among authors: degen jl. Blood. 2005 Jan 1;105(1):178-85. doi: 10.1182/blood-2004-06-2272. Epub 2004 Sep 14. Blood. 2005. PMID: 15367435 Free article.

3

Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo.

Flick MJ, Du X, Degen JL. Flick MJ, et al. Among authors: degen jl. Exp Biol Med (Maywood). 2004 Dec;229(11):1105-10. doi: 10.1177/153537020422901104. Exp Biol Med (Maywood). 2004. PMID: 15564436 Review.

4

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Flick MJ, et al. Among authors: degen jl. J Clin Invest. 2007 Nov;117(11):3224-35. doi: 10.1172/JCI30134. J Clin Invest. 2007. PMID: 17932565 Free PMC article.

5

Fibrinogen deficiency is compatible with the development of atherosclerosis in mice.

Xiao Q, Danton MJ, Witte DP, Kowala MC, Valentine MT, Degen JL. Xiao Q, et al. Among authors: degen jl. J Clin Invest. 1998 Mar 1;101(5):1184-94. doi: 10.1172/JCI1461. J Clin Invest. 1998. PMID: 9486990 Free PMC article.

6

Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms.

Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Palumbo JS, et al. Among authors: degen jl. Blood. 2007 Jul 1;110(1):133-41. doi: 10.1182/blood-2007-01-065995. Epub 2007 Mar 19. Blood. 2007. PMID: 17371949 Free PMC article.

7

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Mullins ES, et al. Among authors: degen sj, degen jl. Blood. 2009 Jan 15;113(3):696-704. doi: 10.1182/blood-2008-07-169003. Epub 2008 Oct 16. Blood. 2009. PMID: 18927430 Free PMC article.

8

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Höök M, Degen JL. Flick MJ, et al. Among authors: degen jl. Blood. 2013 Mar 7;121(10):1783-94. doi: 10.1182/blood-2012-09-453894. Epub 2013 Jan 8. Blood. 2013. PMID: 23299312 Free PMC article.

9

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.

Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. Prasad JM, et al. Among authors: degen jl. Blood. 2015 Oct 22;126(17):2047-58. doi: 10.1182/blood-2015-04-639849. Epub 2015 Jul 30. Blood. 2015. PMID: 26228483 Free PMC article.

10

Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation.

Prasad JM, Negrón O, Du X, Mullins ES, Palumbo JS, Gilbertie JM, Höök M, Grover SP, Pawlinski R, Mackman N, Degen JL, Flick MJ. Prasad JM, et al. Among authors: degen jl. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2009837118. doi: 10.1073/pnas.2009837118. Epub 2020 Dec 21. Proc Natl Acad Sci U S A. 2021. PMID: 33443167 Free PMC article.

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